Modeling dose-dependent temperature responses to methamphetamine
© Molkov et al; licensee BioMed Central Ltd. 2012
Published: 16 July 2012
Amphetamine derivatives are among the most abused drugs in the world. Long-term use can lead to cognitive, neurophysiological, and neuroanatomical deficits. These problems are enhanced by hyperthermia, which itself is a major mortality factor in drug abusers. Temperature responses to amphetamine injections are multiphasic including both hypothermic and hyperthermic phases. These responses are highly dependent on ambient temperature, previous exposure to the drug, and the involvement of various brain areas. It is therefore not surprising that most amphetamine research is performed with only one dose and/or only at one ambient temperature – neither of which may adequately predict real-life situations.
Our results are a promising start to constructing a comprehensive and physiologically relevant model of temperature responses to derivatives of amphetamine. Future will experimentally confirm the identity of the specific brain areas of the interconnected nodes. The power of mathematically modeling is that along with predicting responses to amphetamines in laboratory conditions it may predict scenarios in which life-threatening hyperthermia can occur.
This study was supported by NIH grant DA026867; iM2CS-GEIRE.
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