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  • Poster presentation
  • Open Access

Charge balanced control of seizure like activity in a two dimensional cortical model

BMC Neuroscience201213 (Suppl 1) :P33

  • Published:


  • Partial Differential Equation
  • Feedback Control
  • Spatial Domain
  • Electrical Signal
  • Scale Model

The invasiveness of surgical procedures and the ineffectiveness of medication in remedying seizures in some epileptic patients have led to investigations into alternative methods such as feedback control. While the methods for applying control are varied, the underlying idea is to use electrical signals to disrupt irregular cortical activity. Experimentally, an adaptively applied radial electric field has been shown to control seizure like activity in a mammalian brain [1].

In previous work, a meso scale model consisting of stochastic partial differential equations was developed [2]. Seizure like activity has been simulated with this model, and successfully suppressed using charge balanced electrical control [3]. The magnitude of control was related to the signal sensed at the cortical surface. This work extends previous research to a two dimensional meso scale cortical model. Cortical waves in a two dimensional spatial domain present more complex dynamics than are seen in the one dimensional model, with a greater variety of instabilities of the basic (healthy) states. This presents greater challenges for successful control.



This work has been partly supported by a research grant from the National Science Foundation (NSF).

Authors’ Affiliations

Department of Mechanical Engineering, University of California, Berkeley, CA 94703, USA
Center for Neural Engineering and Prosthesis, UC Berkeley and UC San Francisco, USA


  1. Richardson KA, Gluckman BJ, Weinstein SL: In vivo modulation of hippocampal epileptiform activity with radial electric fields. Epilepsia. 2003, 44 (6): 768-777. 10.1046/j.1528-1157.2003.35402.x.View ArticlePubMedGoogle Scholar
  2. Liley DTJ, Cadusch PJ, Wright JJ: A continuum theory of electro-cortical activity. Neurocomputing. 1999, 26-27: 795-800.View ArticleGoogle Scholar
  3. Lopour BA, Szeri AJ: A model of feedback control for the charge-balanced suppression of epileptic seizures. J Comput Neurosci. 2010, 28: 375-387. 10.1007/s10827-010-0215-x.PubMed CentralView ArticlePubMedGoogle Scholar


© Selvaraj and Szeri; licensee BioMed Central Ltd. 2012

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.