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Cessation of seizure-like oscillations by periodic stimulation in a neuron model with dynamic ion concentrations
© Owen et al; licensee BioMed Central Ltd. 2012
Published: 16 July 2012
In the case of excitatory stimulation, the model continues to exhibit spikes in voltage, but only at the stimulation frequency—which can be made much lower than the rate of spontaneous spiking seen in bursting. For other parameter values, the addition of stimulation can reduce the amplitude of the bursts, or in some cases, induce bursts. These results may give insight into previous studies which showed that stimulation via electrodes can stop seizures in slice preparations , could help explain the mechanism of action of vagus nerve stimulation as treatment for epilepsy , and may provide novel avenues for treatment of epilepsy.
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