- Poster presentation
- Open Access
Cessation of seizure-like oscillations by periodic stimulation in a neuron model with dynamic ion concentrations
© Owen et al; licensee BioMed Central Ltd. 2012
- Published: 16 July 2012
- Nerve Stimulation
- Vagus Nerve
- Phase Plane
- Neuron Model
- Vagus Nerve Stimulation
In the case of excitatory stimulation, the model continues to exhibit spikes in voltage, but only at the stimulation frequency—which can be made much lower than the rate of spontaneous spiking seen in bursting. For other parameter values, the addition of stimulation can reduce the amplitude of the bursts, or in some cases, induce bursts. These results may give insight into previous studies which showed that stimulation via electrodes can stop seizures in slice preparations , could help explain the mechanism of action of vagus nerve stimulation as treatment for epilepsy , and may provide novel avenues for treatment of epilepsy.
- Cressman JR, Ullah G, Ziburkus J, Schiff SJ, Barreto E: The influence of sodium and potassium dynamics on excitability, seizure, and the stability of persistent states:I. Single neuron dynamics. Journal of Computational Neuroscience. 2009, 26 (2): 159-170. 10.1007/s10827-008-0132-4.PubMed CentralView ArticlePubMedGoogle Scholar
- Khosravani H, Carlen PL, Valezsquez JLP: The control of Seizure-Like Activity in the Rat Hippocampal Slice. Biophysical Journal. 2003, 84 (1): 687-695. 10.1016/S0006-3495(03)74888-7.PubMed CentralView ArticlePubMedGoogle Scholar
- Groves DA, Brown VJ: Vagal nerve stimulation: a review of its applications and potential mechanisms that mediate its clinical effects. Neuroscience & Biobehavioral Reviews. 2005, 29 (3): 493-500. 10.1016/j.neubiorev.2005.01.004.View ArticleGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.