A temporal model of neural activity and VSD response in V1
© Stevens and Bednar; licensee BioMed Central Ltd. 2012
Published: 16 July 2012
Mechanistic developmental models of the primary visual cortex (V1) in mammals have been able to replicate many of the large-scale spatial features of V1 neurons from experiments, such as their spatial receptive fields and the spatial organization into maps in V1 (reviewed in ref ). However, the models have previously been formulated at a very abstract level that does not account for the detailed, transient time course of neural responses. Conversely, there are a number of detailed, large-scale spiking models of the adult visual cortex, but these have not explained the development of feature preferences and feature maps, relying instead on prespecified patterns of connectivity. Here we present a new temporally and spatially calibrated model of cortical activity using rate-based units that could help unify these different types of explanation and levels of modelling. The model is called TCAL (Temporally CALibrated), and is a small variant on the GCAL model from the LISSOM family .
The transient responses of LGN neurons in TCAL are due to lateral inhibition between LGN/RGC cells already present in GCAL, but originally for purposes of contrast gain control. The transient responses at the V1 level are partly inherited from LGN but also reflect lateral connectivity in V1, originally for the purposes of map development. TCAL thus shows how the observed transient response properties can arise from the same mechanisms that lead to map development in mechanistic Hebbian models . After calibrating the afferent response delays and distance-dependent lateral connection delays, TCAL can now be used to predict the spatial and temporal time course of voltage-sensitive-dye (VSD) responses to spatiotemporal visual stimuli, and allows the detailed dynamics of perceptual phenomena to be studied even without spiking models.
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