The aim of this study was to investigate changes in network structural properties and functional perturbations of the C. elegans network which were induced by simulated lesions of the neural network through removals of each single neuron (attacks). We analyzed complete neuronal wiring data (i.e. connectome) of the nematode C. elegans [1] consisting of 279 neurons (nodes) and their connections (edges). We constructed the circular wiring diagram of simply combined network of gap junctions and chemical synapses as shown Figure 1. Then, we measured several measures of complex network properties of directed weighted neuronal network of C. elegans to examine the effect of single node attack: the clustering coefficient, global efficiency, isolated nodes, and reachability [2]. We found that the deletions of motor neurons and interneurons were more effective to the clustering coefficient of the network than the sensory neurons. Eliminations of some interneurons mainly decreased global efficiency, and remarkably increased global efficiencies were induced by each removal of sensory neurons (see Table 1). We suggest that this complex network analysis of the c. elegans connectome is helpful for understanding the potential functions of all neurons, and provide insight into which neurons are crucial for specific functions and which neurons are critical for lethality of the network information processing.