Figure 4

Effect of gonadectomy and sex steroid replacement on dopamine metabolic enzyme COMT, MAOA and MAOB mRNA in the substantia nigra of adolescent male rats. (A) COMT mRNA levels were significantly increased by T and DHT when compared to both Gdx and Intact groups. (B) MAOA mRNA and (C) MAOB mRNA levels were significantly increased by T and DHT when compared to both Gdx and Intact groups. * denotes comparisons with the Intact group, # denotes comparisons with the Gdx group. * and #=p < 0.05, ** and ##=p < 0.01, *** and ###=p < 0.0001.