- Poster presentation
- Open Access
Modeling the LFP footprint of unitary thalamic inputs to sensory cortex
BMC Neuroscience volume 12, Article number: P86 (2011)
The depth-resolved synaptic local-field potential (LFP) footprint in sensory cortex following firing in individual thalamic projection neurons can be accurately measured by averaging cortical multielectrode (ME) LFP signals over thousands of spontaneous thalamic firing events [1, 2]. This spike-triggered LFP method offers a unique window into the thalamocortical connection. However, the interpretation of the detailed spatiotemporal profile of this LFP footprint is not trivial as the LFP signal reflects a weighted sum over contributions from all dendritic transmembrane currents located in the vicinity of the recording electrode . We here present results from a biophysically detailed computational study of this LFP footprint, focusing on the thalamocortical LFP response in layer 4 of rodent barrel cortex . As illustrated in Fig. 1, the model considers large populations of synaptically activated RS (regular spiking cells) and/or FS (fast-spiking cells) (Fig. 1AB). The computational model, implemented in Python with NEURON, is constrained to predict plausible intracellular EPSCs  (Fig. 1C) and EPSPs (Fig. 1D). The model not only predicts the LFP (Fig. 1E), but also the ground-truth CSD (current source-density) (Fig. 1F) that can be used to test CSD estimation methods . Candidate models mimicking experimental findings [1, 2] will be presented.
Swadlow HA, Gusev AG, Bezdudnaya T: Activation of a cortical column by a thalamocortical impulse. J Neurosci. 2002, 22: 7766-7773.
Jin J, Wang Y, Swadlow HA, Alonso JM: Population receptive fields of ON and OFF thalamic inputs to an orientation column in visual cortex. Nat Neurosci. 2011, 14: 232-238. 10.1038/nn.2729.
Pettersen KH, Hagen E, Einevoll GT: Estimation of population firing rates and current source densities from laminar electrode recordings. J Comp Neurosci. 2008, 24: 291-313. 10.1007/s10827-007-0056-4.
Hull C, Isaacson JS, Scanziani M: Postsynaptic mechanisms govern the differential excitation of cortical neurons by thalamic inputs. J Neurosci. 2009, 29: 9127-9136. 10.1523/JNEUROSCI.5971-08.2009.
Pettersen KH, Devor A, Ulbert I, Dale AM, Einevoll GT: Current-source density estimation based on inversion of electrostatic forward solution: Effects of finite extent of neuronal activity and conductivity discontinuities. J Neurosci Methods. 2006, 154: 116-133. 10.1016/j.jneumeth.2005.12.005.
Supported by the Research Council of Norway (NevroNor, eNEURO, Notur).
Rights and permissions
This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
About this article
Cite this article
Hagen, E., Fossum, J.C., Pettersen, K.H. et al. Modeling the LFP footprint of unitary thalamic inputs to sensory cortex. BMC Neurosci 12 (Suppl 1), P86 (2011). https://doi.org/10.1186/1471-2202-12-S1-P86
- Projection Neuron
- Recording Electrode
- Firing Event
- Sensory Cortex
- Transmembrane Current