- Poster presentation
- Open Access
Simulated functional networks in health and schizophrenia: a graph theoretical approach
© Cabral et al; licensee BioMed Central Ltd. 2011
- Published: 18 July 2011
- Diffusion Tensor Imaging
- Blood Oxygenation Level Dependent
- Functional Network
- Blood Oxygenation Level Dependent Signal
In the last decade, particular attention has been paid to the graph theoretical aspects of the brain’s network and its implications in brain function. Small-worldness, path length, efficiency and several other graph theoretical metrics have allowed characterizing anatomical and functional network organization.
In a recent study , an analysis of resting-state functional networks of healthy volunteers and people with schizophrenia revealed a number of significant topological differences across groups, namely improved global efficiency, reduced small-worldness, lower clustering, increased hierarchy and greater robustness in patients with schizophrenia compared to healthy subjects. Moreover, these parameters were found correlate with the verbal fluency score, an indicator of disease severity. These results suggest a subtle functional network randomization in schizophrenia. Actually, schizophrenia, characterized by a dysfunctional integration of cognitive processes, is often classified as a disconnection syndrome. This can be understood in terms of abnormal functional connectivity between cortical areas as observed in EEG and fMRI experiments. A disruption of such interactions may therefore underlie the cognitive and behavioral disturbances described in schizophrenia.
In addition, a recent diffusion tensor imaging study  reports an overall lower anatomical connectivity in patients than control subjects. This suggests that the functional network alterations underlying schizophrenia could be originated by a widespread deficit in anatomical coupling.
In the present work we investigated the effect of decreasing the neurodynamical coupling strength in the topological properties of simulated functional networks. We used a large-scale dynamical model of local neural ensembles coupled through anatomical white matter fibers. Spontaneous neuronal activity was obtained from simulations and transformed into blood oxygenation level dependent (BOLD) signal. Functional networks were obtained by computing and thresholding the BOLD signals’ correlation matrix. Graph theoretical measures were then calculated for all the simulated graphs.
Graph theoretical metrics of functional networks in health and schizophrenia
Robustness to Random Attack
Robustness to Targeted Attack
Graph theoretical alterations of functional networks reported in schizophrenia can be accounted for by a decrease in the neurodynamical coupling strength, in agreement with theories of schizophrenia as a disconnectivity syndrome.
- Lynall ME, Bassett DS, Kerwin R, McKenna PJ, Kitzbichler M, Muller U, Bullmore Ed: Functional connectivity and brain networks in schizophrenia. J Neurosci. 2010, 30 (28): 9477-9487.PubMed CentralView ArticlePubMedGoogle Scholar
- Skudlarski P, Jagannathan K, Anderson K, Stevens MC, Calhoun VD, Skudlarska BA, Pearlson G: Brain connectivity is not only lower but different in schizophrenia: a combined anatomical and functional approach. Biological psychiatry. 2010, 68 (1): 61-69. 10.1016/j.biopsych.2010.03.035.PubMed CentralView ArticlePubMedGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.