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A biological plausible recurrent model of V1 hypercolumns

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A biological plausible model of hypercolumn of V1 layer in the Primary Visual Cortex, modeled in the NEST Environment [1], is presented. The model addresses experimental findings on emergence of orientation selectivity which occurs in the V1 [2]. The network model is derived from the Bayesian confidence propagation neural network, which was presented earlier [3, 4]. It is hypothesized that a modular recurrent network model can be used to address orientation selectivity mechanism [2]. Thus, the columnar organization of primary visual cortex is assumed [5]. The network consists of 16 minicolumn models each representing an orientation, ranging from 0o to 168.75o, with the angular distance of 11.25o between two adjacent minicolumn models. LGN input is broadly tuned, half-width of half-height (HWHH) is 40 o. Excitatory->Excitatory network targets all neurons with the probability of 60% inside the host minicolumn with a HWHH of 25o as a function of distance (ESPSs = 3.15 mV). Inhibitory->Excitatory is connected with the probability of 40% (ISPSs = -5.85mV). Excitatory->Inhibitory connections target all neurons with the probability of 40%, and HWHH of 67.5o as a function of distance (ESPSs = 1.35 mV). Furthermore, LGN input is 1/3 of cortical excitation. Hypercolumn model also reflects biological phenomenon of background activity caused by random cortical inputs, as suggested by the experimental findings. In the absence of LGN input, background activity of the population is around 0.5-2 spikes/sec.

Conclusions

LGN input ranges from low to high contrast (5%, 10%, 50%, and 100%), and is fed into the neurons during 2 seconds for each contrast level (mean activities of the excitatory population is shown in Figs 1A and 1B). Simulation results suggest that cortical connections of excitatory and inhibitory neurons play an important role in sharpen of the broadly tuned LGN input. Emergence of contrast invariance of orientation selectivity is also evident (Fig. 1A.). As demonstrated in this specific simulation the cortical network is also efficient in correcting network activity, which is the function of the LGN input solely; when cortical network is absent minicolumn model representing 15 o is most active, whereas in presence of cortical connections 0 o comes out as the winner.

Figure 1
figure1

Mean excitatory population activity. A) Orientation response curves of a cortical hypercolumns. LGN input and cortical excitatory and inhibitory connections are present B) Response to broadly tuned LGN input in absence of cortical excitatory and inhibitory connections.

References

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    Gewaltig MO, Diesmann M: NEST (Neural Simulation Tool). Scholarpedia. 2007, 2 (4): 1430.

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    Ferster D, Miller KD: Neural mechanisms of orientation selectivity in the visual cortex. Annu Rev Neurosci. 2000, 23: 441-471.

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    Curuklu B, Lanser A: An Abstract Model of a Cortical Hypercolumn. Proc. of Int. Conf. on Neural Information Processing. 2002, 80-85.

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    Çürüklü B, Lansner A: Quantitative assessment of the local and long-range horizontal connections within the striate cortex. IEEE Proceedings of the Computational Intelligence, Robotics and Autonomous Systems. 2003

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    Mountcastle VB: The columnar organization of the neocortex. Brain. 1997, 120: 701-722.

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Correspondence to Atahan Afşar.

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This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Afşar, A., Ulubilge, T. & Çürüklü, B. A biological plausible recurrent model of V1 hypercolumns. BMC Neurosci 12, P48 (2011) doi:10.1186/1471-2202-12-S1-P48

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Keywords

  • Background Activity
  • Primary Visual Cortex
  • Cortical Network
  • Recurrent Network
  • Orientation Selectivity