Modeling UBC intrinsic excitability
© Subramaniyam et al; licensee BioMed Central Ltd. 2011
Published: 18 July 2011
Here we present a biologically realistic multi-compartmental mathematical model of the UBC realized with the NEURON simulator. According to literature [1–4], ionic channels are distributed among compartments (soma, dendrite, and axon). The model can reproduce the excitable properties of UBCs in current-clamp and voltage-clamp modes. Attempts at modeling the response to mossy fiber inputs are ongoing. This model confirms the primary role of the aforementioned currents in UBC’s electroresponsiveness. The model will also be a valuable tool for investigating the UBC’s function in the cerebellar network.
This work was supported by the EU projects CEREBNET and REALNET to ED. SS is recipient of a grant from CEREBNET.
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