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Identifying dendritic processing in a [Filter]-[Hodgkin Huxley] circuit
BMC Neuroscience volume 12, Article number: P306 (2011)
The nature of encoding and processing of sensory information in the visual, auditory and olfactory systems has been extensively investigated in the systems neuroscience literature. Many phenomenological  as well as mechanistic  models have been proposed to characterize and clarify the representation of sensory information on the level of single neurons. In  we presented a novel methodology for identifying dendritic processing in phenomenological neural circuit models in which the time-domain linear processing takes place in the dendritic tree and the resulting aggregate dendritic current is encoded in the spike domain by a spiking neuron. In block-diagram form, these neural circuit models are of the [Filter]-[Spiking Neuron] type and as such represent a fundamental departure from the standard Linear-Nonlinear-Poisson (LNP) model that has been used to characterize neurons in many sensory systems, including vision , audition  and olfaction . While the LNP model also includes a linear processing stage, it describes spike generation using an inhomogeneous Poisson process. In contrast, the [Filter]-[Spiking Neuron] model incorporates the temporal dynamics of spike generation and allows one to consider biophysically inspired spike generators.
Here we extend the dendritic identification results of  to spiking neurons with random parameters and consider a more general model of dendritic processing. As before, we assume that input stimuli belong to the space of bandlimited functions, but now formulate the filter identification problem using the theory of smoothing splines. This alternative formulation allows us to take into account noise sources inherently present in biological neurons and makes our methods amenable to modeling neural circuits that arise in systems neuroscience. First, we construct an optimal estimate of the dendritic processing filter in a neural circuit consisting of a filter in cascade with an ideal integrate-and-fire (IAF) neuron with random threshold (RT), also abbreviated as the [Filter]-[Ideal IAF/RT] circuit. Second, we demonstrate that our basic method can be extended to identify the dendritic processing filter in cascade with a Hodgkin-Huxley (HH) neuron with stochastic conductances (SC). We then investigate two different ways in which a stimulus can be coupled to a HH neuron: multiplicative coupling ([Filter]-[HH/SC/MC] circuit)  and additive coupling ([Filter]-[HH/SC/AC] circuit). We also show that using conditional phase response curves (cPRCs)  it is possible to identify the dendritic processing filter using both weak and strong input stimuli. Third, we demonstrate that the presented methodology is very general and can be employed by system neuroscientists to model neural circuits using a (biophysical) neuron model of their choice. Specifically, we show that the above identification methods can be readily applied to any neural (nonlinear dynamical) system with a limit cycle, including FitzHugh-Nagumo, Morris-Lecar and INa,p + IK models.
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The work presented here was supported by NIH under the grant number R01DC008701-01.