Dendritic versus somatic resonance
© Zhuchkova and Schreiber; licensee BioMed Central Ltd. 2011
Published: 18 July 2011
Membrane-potential resonance characterizes the ability of a neuron to selectively respond to stimuli in a preferred frequency band. It has been associated with the occurrence of subthreshold membrane-potential oscillations (MPOs) and has been shown to be of functional relevance, as exemplified by the correlation of resonance frequencies with the spacing of grid fields in the entorhinal cortex  and the dependence of this spacing on the resonating H current .
Resonance arises from the interaction of passive and active membrane properties, usually requiring the presence of slowly-activating conductances that act as high-pass filters and are able to effectively oppose slow changes of the membrane potential. The distribution of slow conductances responsible for resonance (like H or M), however, can differ between the compartments within a neuron. In CA1 neurons, for example, it is known that the density of H channels increases by more than 60-fold from soma to dendrites and is largest in the distal parts of the dendritic tree . Accordingly, resonance can also depend on the spatial localization within a cell. Still, cells are usually classified as either resonant or nonresonant on the basis of somatic injection of ZAP currents (sine-wave functions with a linear increase in frequency).
Here, we investigate to what extent and under which circumstances cells with dendritic resonance may be misclassified as nonresonant by somatic measurement of resonance properties. We use simple conductance-based multicompartmental models to analyze the effect of dendritic resonance on somatic input (and hence resonance estimates based on somatic recordings). We find that indeed, even a strong dendritic resonance may not be detectable with somatic ZAP protocols. The extent to which dendritic resonance is masked depends on neuronal morphology as well as the distribution of active conductances within the cell. In addition, we show that although dendritic resonance may not show up somatically, indirect consequences of dendritic resonance can affect the soma. In particular, MPOs of dendritic resonance-induced origin may propagate to the soma, leading to a situation where such cells when measured somatically do exhibit subthreshold MPOs in the apparent "absence" of resonance.
A local dendritic resonance filters dendritic inputs - even if it should not show up somatically - and is hence crucial for the flow of information in neuronal networks. It is therefore important to identify the circumstances under which dendritic resonance could be missed in somatic assessment of resonance properties.
This work was supported by the DFG (SFB 618) and the BMBF (BCCN Berlin, BPCN).
- Giocomo LM, Zilli EA, Francen E, Hasselmo ME: Temporal frequency of subthreshold oscillations scales with entorhinal grid cell field spacing. Science. 2007, 315: 1719-1722. 10.1126/science.1139207.PubMed CentralView ArticlePubMedGoogle Scholar
- Giocomo LM, Hasselmo ME: Knock-out of HCN1 subunit flattens dorsal-ventral frequency gradient of medial entorhinal neurons in adult mice. J Neurosci. 2009, 29: 7625-7630. 10.1523/JNEUROSCI.0609-09.2009.PubMed CentralView ArticlePubMedGoogle Scholar
- Lorincz A, Notomi T, Tamas G, Shigemoto R, Nusser Z: Polarized and compartment-dependent distribution of HCN1 in pyramidal cell dendrites. Nat Neurosci. 2002, 5: 1185-1193. 10.1038/nn962.View ArticlePubMedGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.