Possible mechanisms underlying intermittent synchronous activity in the networks of excitatory and inhibitory bursting neurons
© Park and Rubchinsky; licensee BioMed Central Ltd. 2011
Published: 18 July 2011
Basal ganglia circuits in Parkinson’s disease constitute a prominent example of neural system of coupled inhibitory and excitatory neurons, which exhibit synchronous activity . The phase-locking of neural activity in this system, as analyzed in experimental data intraoperatively recorded in Parkinsonian patients, exhibits intermittent temporal dynamics . The mechanisms of this intermittent synchronous dynamics make the subject of this study.
We used geometric dynamical systems and singular perturbation methods to reduce the full model to a simpler set of equations. Mathematical analysis was completed using three slow variables with two different time scales. Intermittently synchronous oscillations are generated by overlapped spiking which crucially depend on the geometry of slow phase plane and the interplay between slow variables as well as the strength of synapses. Two slow variables are responsible for the generation of out-of-phase stable solution and the other slower variable for irregular and intermittent activity pattern. The results of analysis can be traced to particular values of biophysical parameters (synaptic strength and parameters of calcium dynamics), which are known to be impacted in Parkinson’s disease.
This study was supported by NIH grant R01NS067200 (NSF/NIH CRCNS program).
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