Does the information in the phase of low frequency LFP reflect the low frequency envelope of local spike rates?
© Siadatnejad et al; licensee BioMed Central Ltd. 2011
Published: 18 July 2011
Recently, it has been shown that when the timing of spikes is measured relative to the phase of the cortical local field potentials (LFP), spikes can carry substantial more information about an external stimulus . Experimental studies in sensory cortices of macaque have shown that the extra information obtained with such phase-of-firing codes above that in the firing rate alone ranges from 55% in primary visual cortex  to more than 100% in primary auditory cortex . Here, we use a mathematical model that relates local spike trains and the resulting LFP, to explain the emergence of the phase-of-firing codes in cortex. The model is based on the one proposed in  and incorporates two types of integration over the spiking activity: i) a time convolution that results from the filtering properties of neural structures , which embeds history effects in LFP from past spiking activity, and ii) an integration step over the activity of neurons in the neighbourhood of the measuring electrode.
MAM and SP acknowledge support from the UK Engineering and Physical Sciences Research Council (EPSRC) grant EP/C010841/1 (COLAMN)
- Montemurro MA, Rasch MJ, Murayama Y, Logothetis NK, Panzeri S: Phase-of-firing coding of natural visual stimuli in primary visual cortex. Curr Biol. 2008, 18 (5): 375-80. 10.1016/j.cub.2008.02.023.View ArticlePubMedGoogle Scholar
- Kayser C, Montemurro MA, Logothetis NK, Panzeri S: Spike-phase coding boosts and stabilizes information carried by spatial and temporal spike patterns. Neuron. 2009, 61 (4): 597-608. 10.1016/j.neuron.2009.01.008.View ArticlePubMedGoogle Scholar
- Bédard C, Kröger H, Destexhe A: Does the 1/f Frequency Scaling of Brain Signals Reflect Self-Organized Critical States?. Phys. Rev. Lett. 2006, 97: 118102-10.1103/PhysRevLett.97.118102.View ArticlePubMedGoogle Scholar
- Pettersen KH, Einevoll GT: Amplitude Variability and Extracellular Low-Pass Filtering of Neuronal Spikes. Biophys J. 2008, 94 (3): 784-802. 10.1529/biophysj.107.111179.PubMed CentralView ArticlePubMedGoogle Scholar
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