A computational model of a strongly facilitating synapse
© Jędrzejewska-Szmek et al; licensee BioMed Central Ltd. 2011
Published: 18 July 2011
We propose a new model of strongly facilitating synapse. It is described in terms of resources R which can be in two states: available and inactivated (recovery constant –t γ ). It assumes that for the release of neurotransmitter to the synaptic cleft a fraction (u) of available resources must bu used (as in ). This fraction is elevated by every AP (by a factor ~ u*U) and decays in between APs (facilitation constant – t f ). u related to the calcium concentration. It is further assumed that the activation of the neurotransmitter release machinery requires binding of 5 calcium ions to synaptotagmin, binding synaptic vesicles to the presynaptic membrane. Hence the postsynaptic current is proportional to u5*R*δ(t-tAP).
Results of the models fit to the experimental data
Value and 68% confidence range in
10± 2 ms
0.18 ± 0.07
- Thomson AM: Activity-dependent properties of synaptic transmission at two classes of connections made byrat neocortical pyramidal axons in vitro. J Physiol. 1997, 502: 131-147. 10.1111/j.1469-7793.1997.131bl.x.PubMed CentralView ArticlePubMedGoogle Scholar
- Markram H, Wang Y, Tsodyks M: Differential signaling via the same axon of neocortical pyramidal neurons. Proc Natl Acad Sci U S A. 1998, 95 (9): 5323-532. 10.1073/pnas.95.9.5323.PubMed CentralView ArticlePubMedGoogle Scholar
- Fuson KL, Montes M, Robert JJ, Sutton RB: Structure of human synaptotagmin 1 C2AB in the Absence of Ca2+ reveals a novel domain association. Biochemistry. 2007, 46: 13041-13048. 10.1021/bi701651k.View ArticlePubMedGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.