- Poster Presentation
- Open Access
Autaptic excitation contributes to bistability and rhythmicity in the neural circuit for feeding in Aplysia
BMC Neuroscience volume 11, Article number: P58 (2010)
The feeding circuit in Aplysia is a useful model system for studying the neuronal bases of cognitive functions such as sensory processing, generation of behavior, motivation, decision making, learning, and memory [1, 2]. The goals of the present study are to develop a biologically-realistic model of the feeding circuit and to investigate the ways in which component processes contribute to circuit function. To begin, we developed a model of the central pattern generator (CPG) that mediates rhythmicity in the feeding circuit (Fig. 1A). Simulations indicated that two positive-feedback loops (the B31 autapse and the synaptic interactions between B31 and B63) introduced bistability into the membrane potential of the B31 soma (Figures 1B, 1C1). In addition, simulations indicated that this plateau-like potential was the ‘deciding factor’ for initiating rhythmic activity (Fig. 1C). Simulations also helped identify features of the model that warrant further empirical investigation; e.g., the simulated amplitude of the plateau-like potential was less than empirical observations.
Baxter DA, Byrne JH: Feeding behavior of Aplysia: a model system for comparing cellular mechanisms of classical and operant conditioning. Learn Mem. 2006, 13: 669-680. 10.1101/lm.339206.
Cropper EC, Evans CG, Hurwitz I, Jing J, Proekt A, Romero A, Rosen SC: Feeding neural networks in the -mollusc Aplysia. Neurosignals. 2004, 13 (z): 70-86. 10.1159/000076159.
Cataldo E, Byrne JH, Baxter DA: Computational model of a central pattern generator. Lec Not Comput Sci. 2006, 4210: 242-256. full_text.
Baxter DA, Byrne JH: Simulator for neural networks and action potentials. Methods Mol Biol. 2007, 401: 127-154. (SNNAP is available at http://www.snnap.uth.tmc.edu)
Hurwitz I, Ophir A, Korngreen A, Koester J, Susswein AJ: Currents contributing to decision making in neurons B31/32 of Aplysia. J Neurophysiol. 2008, 99: 814-830. 10.1152/jn.00972.2007.
This work was supported by NIH grant P01 NS038310.
About this article
Cite this article
Baxter, D.A., Cataldo, E. & Byrne, J.H. Autaptic excitation contributes to bistability and rhythmicity in the neural circuit for feeding in Aplysia. BMC Neurosci 11, P58 (2010) doi:10.1186/1471-2202-11-S1-P58
- Animal Model
- Decision Making
- Cognitive Function
- Membrane Potential
- Pattern Generator