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The perturbation response and power spectrum of a mean-field of IF neurons with inhomogeneous inputs
BMC Neuroscience volume 11, Article number: P44 (2010)
The aim of this study is to construct a bottom-up model of cortical dynamics that is capable of describing the same types of neural phenomena as top-down continuum models, namely the power spectrum, frequency response to perturbation and EEG time-series. The key difference between the two approaches is that the bottom-up approach preserves more of the intrinsic physiological details than the top-down models . A stochastic Fokker-Planck modelling approach is used to describe a network of leak integrate-and-fire (IF) neurons with temporally inhomogeneous inputs. Previous work either calculated the response of a single neuron with conductance-based synapses, or the network with current-based synapses . In this study we use and extend a recently published Fokker-Planck approach  within an analytical framework to calculate the dynamical firing-rate of a network with conductance-based synapses receiving temporally inhomogeneous synaptic input. In particular, the network has fully recurrent connectivity with both the steady-state and the dynamic perturbation response of the background activity fed back into the inputs. This is done in a self-consistent formalism  for a network of excitatory and inhibitory neurons.
The Fokker-Planck formalism enables the calculation of the linear response of the firing-rate to perturbation with recurrent connections. The power spectrum and EEG time-series of the network are calculated by treating the synaptic inputs as an inhomogeneous Poisson process. From this we determine the auto-correlation function, which is identified as a cyclo-stationary process. The signal is then phase-averaged over its period and the Wiener-Khinchin theorem is used to determine the power spectrum from the autocorrelation function. The power spectrum is convolved with a filter to approximate the local field potential propagation through the extra-cellular fluid .
The analytical results of the frequency response of the dynamical firing rate and its power spectra are compared with numerical simulation results for a recurrently connected network with conductance-based synapses and temporally inhomogeneous inputs. Results are obtained using parameter values that represent typical cortical in vivo neurons . This work is the first stage necessary for constructing a physiologically plausible mathematical model of a mesoscopic network of cortical columns.
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This work was funded by the Australian Research Council (ARC Linkage Project #LP0560684).
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Peterson, A.D., Meffin, H., Burkitt, A.N. et al. The perturbation response and power spectrum of a mean-field of IF neurons with inhomogeneous inputs. BMC Neurosci 11, P44 (2010). https://doi.org/10.1186/1471-2202-11-S1-P44
- Power Spectrum
- Synaptic Input
- Cortical Column
- Recurrent Connection
- Inhomogeneous Poisson Process