Neural field model of rat's cortex based on realistic connectivity from diffusion weighted MRI and neural morphology
© Trong et al; licensee BioMed Central Ltd. 2010
Published: 20 July 2010
Generative models of neural circuits may help to create a link between neural mechanisms and observable data. We propose a model of rat's cortex using a neural field model containing biologically plausible anatomical connections from tractography based on dwMRI data and from the neural morphological database NeuroMorpho .
There are three principal types of anatomical connections in the cortex: Local, long-range and distal connections .
For specifying local connections we use neural morphologies from . We consider each voxel in the model as a neural mass and distribute randomly drawn neurons from the database therein. After that we use bootstrap methods to determine the total number and variability of synaptic contacts. For the distal connectivity we estimated the degree of anatomical connectedness using white matter tractography on the basis of diffusion weighted MRI .
Our neural field consists of 5 layers. For each layer we assume three different neural masses: pyramidal cells, excitatory and inhibitory interneurons . The mutual interactions between neural masses will be described by a system of integral differential equations:
To summarize, we developed a method for estimating the local connectivity and constructed a neural field model of the entire cortex enriched by estimated local and distal connectivities. With this model we are able to simulate spatio-temporal activity patterns. This is a first step for a comprehensive dynamic brain model and thereby for understanding complex brain processes.
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