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Computational analysis of the functional role of cerebellar Basket-type inhibitory connections: compensation or coding?

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Despite the morphological changes observed within the cerebellum over the course of evolution, its circuitry with respect to its neuronal types, have remained a remarkable constant [1]. In particular, the relationship between the geometry of the Purkinje cells and the parallel fiber projection of the cerebellar granule cells has been observed in all vertebrates [2]. However, one clear comparative difference is the fact that basket-type inhibitory connections to the soma of the Cerebellar Purkinje cells are only found in birds and mammals [3]. The objective of this study was to test the model-based predication [4] that these basket inhibitory inputs serve to control the excitatory effects of the larger number of parallel fiber inputs found in birds and mammals.

In the first phase of this project, cell-counting techniques have been used to obtain the ratio of granule cells to Purkinje cells in a wide range of vertebrate animals. These results suggest that, in fact, larger GC:PC ratios are found in birds and mammals. The results to be presented here were obtained by first using 3D neuronal reconstruction techniques to characterize the shapes of the dendrites and somata of cerebellar Purkinje cells from fish, turtles, rats and birds. These morphologies were then used to create compartmental single cell models which, in turn, were used to explore the cells passive electrical properties. Parameters explored include the maximal amplitude, time to reach maximal amplitude, voltage drops, and the standard deviation from the average membrane potential during spiking. All procedures were conducted under the approval and supervision of the Animal Welfare and Use Committee. All simulations were conducted using GENESIS 3.0. The results suggest that the Purkinje cells of birds and mammals are more electronically compact than are those of turtles and fish.

Taken together, these results support the hypothesis that the basket-type inhibitory connection evolved to compensate for both an increase in the number of parallel fiber inputs per Purkinje cell as well as in the computational speed of processing of the Purkinje cell. The results will be interpreted in the context of our network model of cerebellar cortical circuitry.

References

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    Llinás RR, Walton KD, Lang EJ: Cerebellum. The Synaptic Organization of the Brain. 2004, Shepard GM, editor. Oxford University Press., 271-309. 5th.

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    Bell C: Evolution of cerebellum-like structures. Brain Behav Evol. 2002, 59: 312-326.

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    Larsell O: The Comparative Anatomy and Physiology of the Cerebellum. 1972, University of Minnesota Press.

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    Santamaria F, Tripp P, Bower JM: Feedforward inhibition controls the spread of granule cell-induced Purkinje cell activity in the cerebellar cortex. J. Physiology. 2007, 97: 248-263.

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Acknowledgements

Supported by a grant from the National Science Foundation

Author information

Correspondence to Rachael Wilcox.

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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Wilcox, R., Cornelis, H. & Bower, J.M. Computational analysis of the functional role of cerebellar Basket-type inhibitory connections: compensation or coding?. BMC Neurosci 11, P141 (2010) doi:10.1186/1471-2202-11-S1-P141

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Keywords

  • Purkinje Cell
  • Granule Cell
  • Cerebellar Granule
  • Cerebellar Granule Cell
  • Parallel Fiber