A combined computational-experimental study of dynamic responses to olfactory input in a glomerular circuit
© Carey et al; licensee BioMed Central Ltd. 2010
Published: 20 July 2010
Odorant-evoked input to and output from the mammalian olfactory bulb (OB) is temporally dynamic. Olfactory receptor neuron (ORN) inputs are tightly coupled to the respiratory cycle, and inhalation-evoked input bursts occur with durations, rise times, latencies, and strengths (amplitudes) that vary across glomeruli (for the same odorant) and also in individual glomeruli for different odorants . The temporal spread of sensory input following a single inhalation (~100-300 ms) is comparable to the range of discrimination times for different olfactory tasks [2, 3], consistent with these dynamics being important in shaping odor perception. Similarly diverse temporal patterns of activity occur at the level of output from the OB, among mitral cells (MCs), whose firing patterns express strong temporal structure organized around the respiratory cycle and modulated by odorant presentation; significant odor information is carried in these temporal patterns across the MC population.
- Carey RM, Verhagen JV, Wesson DW, Wachowiak M: Temporal Structure of Receptor Neuron Input to the Olfactory Bulb Imaged in Behaving Rats. J. Neurophysiol. 2009, 101: 1073-1088. 10.1152/jn.90902.2008.PubMed CentralView ArticlePubMedGoogle Scholar
- Abraham NM, Spors H, Carleton A, Margrie TW, Kuner T, Schaefer AT: Maintaining accuracy at the expense of speed: stimulus similarity defines odor discrimination time in mice. Neuron. 2004, 44: 865-876.PubMedGoogle Scholar
- Wesson DW, Donahou TN, Johnson MO, Wachowiak M: Sniffing behavior of mice during performance in odor-guided tasks. Chemical Senses. 2008, 33: 581-596. 10.1093/chemse/bjn029.PubMed CentralView ArticlePubMedGoogle Scholar
- Bathellier B, Lagier S, Faure P, Lledo PM: Circuit properties generating gamma oscillations in a network model of the olfactory bulb. J Neurophysiol. 2006, 95: 2678-2691. 10.1152/jn.01141.2005.View ArticlePubMedGoogle Scholar
- Verhagen JV, Wesson DW, Netoff TI, White JA, Wachowiak M: Sniffing controls an adaptive filter of sensory input to the olfactory bulb. Nat Neurosci. 2007, 10: 631-639. 10.1038/nn1892.View ArticlePubMedGoogle Scholar
- De Saint Jan D, Hirnet D, Westbrook GL, Chupak S: External Tufted Cells Drive the Output of Olfactory Bulb Glomeruli. J. Neurosci. 2009, 29 (7): 2043-2052. 10.1523/JNEUROSCI.5317-08.2009.View ArticlePubMedGoogle Scholar
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