Methods
We have produced a stochastic computer model that incorporates KCa channels and calcium dynamics into a CA3 pyramidal neuron, which is based on the biophysically realistic Traub model [3]. To introduce channel noise, we replaced all Hodgkin-Huxley (HH) channels with equivalent Markov models [4]. There is also an intracellular calcium pool, with Ca2+ levels that vary stochastically due to influx through Markovian calcium channels.