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Volume 11 Supplement 1

Nineteenth Annual Computational Neuroscience Meeting: CNS*2010

Computational modeling of Basal Ganglia: towards a mechanism of high frequency stimulation

BMC Neuroscience volume 11, Article number: P113 (2010) Cite this article

Deep Brain Stimulation(DBS) with 130Hz represents an effective therapy to alleviate symptoms of some neurodegenerative diseases such as Parkinson syndrome [1]. However the mechanism underlying the observed improvement in patient's symptoms is still under dispute. Modeling of its mechanism was first done with the Albin-Delong [2] model, which assumed two discriminated feedforward projections, from the input stage Striatum to the output stage Globus pallidus internal (GPi) and Substantia Nigra pars reticulata (SNr). However, this influential contribution neither took motor control into account nor the evidence for a selective of effect high frequency stimulation [3–5]. This study tries to model the underlying network with increasing realistic complexity and presents a spiking network model based on Izhikevich type neurons [6]. Our currently simulated model examines the firing patterns variability between GABAergic STN neuron projections depending on the firing rate. It shows features like synchronous, rythmic population spike found in experimental data of pyramidal interneuronal network [7].

References

  1. Obeso JA, Olanow CW, Rodriguez-Oroz MC, Krack P, Kumar R, Lang AE: Deep-brain stimulation of the subthalamic nucleus or the pars interna of the globus pallidus in Parkinson’s disease. N Engl J Med. 2001, 345: 956-63. 10.1056/NEJMoa000827.

    Article  Google Scholar 

  2. Albin RL, Young AB, Penney JB: The functional anatomy of basal ganglia disorders. Trends Neurosci. 1989, 12: 366-375. 10.1016/0166-2236(89)90074-X.

    Article  CAS  PubMed  Google Scholar 

  3. Hiller A, Loeffler S, Haupt Ch, Litza M, Hofmann U, Moser A: Electrical High Frequency Stimulation Induces GABA Outflow in Freely Moving Rats. J Neurosci Methods. 2007, 159: 286-290. 10.1016/j.jneumeth.2006.07.023.

    Article  CAS  PubMed  Google Scholar 

  4. Li T L, Thümen A, Moser A: Modulation of a neuronal network by electrical high frequency stimulation in striatal slices of the rat in vitro. Neurochem. Int. 2006, 48: 83-86. 10.1016/j.neuint.2005.09.004.

    Article  CAS  PubMed  Google Scholar 

  5. Mantovani M, Haas CA, Zentner J, Moser A, Feuerstein TJ: GABAA autoreceptors enhance GABA release from human neocortex: towards a mechanism for high-frequency stimulation (HFS) in brain.

  6. Izhikevich EM: Simple model of Spiking Meurons. IEEEE Transact. Neural Netw. 2003, 14 (6).

  7. Börgers C, Kopell N: Synchronization in Networks of Excitatory and Inhibitory Neurons with Sparse, Random connectivity. Neural Comput. 2003, 15: 509-538. 10.1162/089976603321192059.

    Article  PubMed  Google Scholar 

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Acknowledgement

This work was supported by the Graduate School for Computing in Medicine and Life Sciences funded by Germany’s Excellence Initiative [DFG GSC 235/1].

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Authors and Affiliations

  1. Institute for Signal Processing, University of Lübeck, Lübeck, D-23538, Germany

    Félix Njap, Simon Vogt & Ulrich Hofmann

  2. Graduate School for Computing medicine and Life Sciences, Lübeck, D-23538, Germany

    Félix Njap

  3. Department of Neurology, University of Lübeck, Lübeck, D-23538, Germany

    Andréas Moser

Authors
  1. Félix Njap
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  2. Andréas Moser
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  3. Simon Vogt
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  4. Ulrich Hofmann
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Corresponding author

Correspondence to Félix Njap.

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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Njap, F., Moser, A., Vogt, S. et al. Computational modeling of Basal Ganglia: towards a mechanism of high frequency stimulation. BMC Neurosci 11 (Suppl 1), P113 (2010). https://doi.org/10.1186/1471-2202-11-S1-P113

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  • DOI: https://doi.org/10.1186/1471-2202-11-S1-P113

Keywords

  • Neurodegenerative Disease
  • Firing Rate
  • Deep Brain Stimulation
  • Neuron Projection
  • Firing Pattern

BMC Neuroscience

ISSN: 1471-2202

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