Disease Model | LTP | LTD | Inhibition | Connectivity |
---|---|---|---|---|
Neurodevelopmental | ||||
Angelman synd. | Â | Â | Decreased [47] | |
   Ube3A KO |  |  |  |  |
Down synd. | Increased [51] | |||
   Trisomy |  |  |  |  |
Fragile × synd. | Increased [57] | |||
   Fmr1 KO |  |  |  |  |
FRAXE synd. | Increased [61] | Â | Â | Â |
   Fmr2 KO |  |  |  |  |
Neurofibromat. | Â | Â | ||
   Nf1 het |  |  |  |  |
Rett synd. | Decreased [65] | Increased [67] | ||
   Mecp2 KO |  |  |  |  |
Tuberous Scler. | Decreased [70] | Decreased [70] | Â | |
   Tsc1 KO |  |  |  |  |
   Tsc2 KO (rat) |  |  |  |  |
Various XLMR | Decreased [75] | Â | Â | |
   Ophn1 KO |  |  |  |  |
   Pak3 KO |  |  |  |  |
   Gdi1 KO |  |  |  |  |
Neuropsychiatric | ||||
Schizophrenia | Decreased [78] | Decreased [78] | ||
   Disc1 mut |  |  |  |  |
   Reelin het |  |  |  |  |
   22q11 del |  |  |  |  |
Neurodegenerative | ||||
ALS | Increased [82] | Â | Â | Decreased [83] |
   Sod1 mut |  |  |  |  |
Alzheimer's | Â | |||
   App mut |  |  |  |  |
   Ps1/Ps2 KO |  |  |  |  |
   App/Ps1 mut |  |  |  |  |
Huntington's | Â | Â | ||
   Htt mut |  |  |  |  |
Parkinson's. | Decreased [94] | Â | Â | |
   Dj-1 KO |  |  |  |  |
   Parkin KO |  |  |  |  |
SCA | Â | Â | Decreased [98] | |
   Sca1 mut |  |  |  |  |
   Fgf14 KO |  |  |  |  |