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An analytical solution of the cable equation predicts the frequency preference of a passive non-uniform cylindrical cable in response to extracellular oscillating electrical fields
BMC Neuroscience volume 10, Article number: P38 (2009)
Under physiological and artificial conditions, the dendrites of neurons can be exposed to electrical fields [1–3]. Recent experimental studies suggested that the membrane resistivity of the distal apical dendrites of cortical and hippocampal pyramidal neurons may be significantly lower than those of the proximal dendrites and the soma [4–6]. To understand the behavior of dendrites in time varying extracellular electrical fields, we obtained analytical solutions of the cable equation for finite cylindrical cables with and without a leak conductance at one end by employing the Green's function method. The solution of a cable with leak at one end for DC electrical fields shows a reversal of polarization at the leaky end (Figure 1), as has been shown previously by employing the method of variable separation and Fourier expansion . The solution of a cable with leak at one end for AC electrical fields shows that the leaky end has a frequency preference in the response amplitude (Figure 2).
Our results suggest that a passive dendrite with low resistivity at the distal end would show a frequency preference in response to sinusoidal extracellular local field potentials. The Green's function obtained in our study can be used to calculate response for any form of extracellular electrical field.
Bikson M, et al: Effects of uniform extracellular DC electrical fields on excitability in rat hippocampal slices in vitro. J Physiol. 2004, 557: 175-195. 10.1113/jphysiol.2003.055772.
Faber DS, Korn H: Electrical Field Effects: Their relevance in central neural networks. Physiol Review. 1989, 69: 821-863.
Jefferys JGR: Nonsynaptic modulation of neuronal activity in the brain: Electric currents and extracellular ions. Physiol Review. 1995, 75: 689-723.
Inoue M, et al: Dendritic attenuation of synaptic potentials in the CA1 region of rat hippocampal slices detected with an optical method. Eur J Neurosci. 2001, 13: 1711-1721. 10.1046/j.0953-816x.2001.01550.x.
Omori T, et al: Estimated Distribution of Specific Membrane Resistance in Hippocampal CA1 Pyramidal Neuron. Brain Research. 2006, 1125: 199-208. 10.1016/j.brainres.2006.09.095.
Stuart G, Spruston N: Determinants of voltage attenuation in neocortical pyramidal neuron dendrites. J Neurosci. 1998, 18: 3501-3510.
Svirskis G, et al: Detection of a Membrane Shunt by DC Field Polarization during Intracellular and Whole Cell Recording. J Neurophysiol. 1997, 77: 579-586.