Quantitative modeling of the dynamics of adult hippocampal neurogenesis in mice
© Lezius et al; licensee BioMed Central Ltd. 2009
Published: 13 July 2009
The hippocampus is special in that it generates new neurons throughout life. This development of new granule cells in the adult dentate gyrus is referred to as adult hippocampal neurogenesis. A kinetic model of this development has been established . Therein the process of neurogenesis is composed of a sequence of different cell types. However, the exact dynamics of neuronal development in the dentate gyrus are unknown. To quantify the development we collected time-series like data. By injections of BrdU, the dividing cells were labeled and cell numbers could be counted at different time points after injection (2 h to 21 d). We determined relative numbers of BrdU-positive cells of the respective types. These numbers allow us to monitor the development of a labeled cell cohort through the different cell types over the analyzed time period. We also determined absolute cell numbers of different unlabeled populations. They do not show a time dependence, which leads to the idea of a dynamic equilibrium of cells of the different cell types on the analyzed timescale.
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