Volume 10 Supplement 1
KIR channels in nucleus accumbens MS neurons modulate integration of excitatory synaptic inputs: a computational study
© John and Manchanda; licensee BioMed Central Ltd. 2009
Published: 13 July 2009
Nucleus accumbens (NAc) is a major site of action for many drugs of abuse and is implicated in brain disorders like schizophrenia . NAc MS neurons possess an array of active channels (14 channels) that may influence their information processing . Experimental studies on the electrophysiological properties of the dendrites of MS neurons are very sparse due to their tiny structure. Here we use a computational model of the NAc MS neurons to investigate the role of KIR currents in the integration of excitatory synaptic inputs.
Using NEURON, a 189-compartment model of MS cell was built based on Wolf et al, 2005 . Co-localized NMDA-AMPA synapses were used to generate EPSPs.
Thus, KIR currents significantly affect propagation and normalization of synaptic potentials in MS neurons. In view of the fact that dopamine powerfully modulates KIR conductance in MS neurons KIR channels may play an important role in setting the cell excitability in response to external modulatory influences.
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This article is published under license to BioMed Central Ltd.