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Control of bursting activity by modulation of ionic currents
BMC Neuroscience volume 10, Article number: P27 (2009)
Our study is focused on modulation of dynamics of single leech heart interneurons (HNs). We consider two models of HNs representing these neurons under two different pharmacological treatments: (1) blocking of Ca2+ currents and inhibitory coupling with the Ca2+-containing saline and partial blocking of K+ currents; (2) decoupling HNs with bicuculline. In (1), an HN demonstrates slow plateau-like oscillations [1, 2]. In (2), an HN demonstrates endogenously bursting activity . We analyze how the interburst interval and burst duration could be controlled by manipulating hyperpolarization-activated current, I h , and persistent Na+ current, I P , namely by variation of their conductances and the half-activation voltages, V1/2. For example, burst duration increases greatly from 1.7 s to 8.9 s as Vh,1/2increased from -30 mV to 4 mV. The interburst interval grows from 0.6 s to 125 s as the Vh,1/2decreases from 4 [mV] to -56 [mV] in accordance with a saddle-node bifurcation. In (2), we similarly show that the variation of Vh,1/2could be a target for modulation of the bursting. In both cases, we show co-existence of bursting and silence. Interestingly, the co-existence is sensitive to g h (and to maximal conductance of fast Ca2+ current, gCaF too in (2)) and is not sensitive to the maximal conductances of other currents. In (1), if g h is increased from 4 nS to 8 nS, the bistability is then observed in an almost five-fold larger range of the leak conductance values, gleak. In (2), if either g h is changed from 4 nS to 8 nS or gCaF is changed from 5 nS to 0 nS, the bistability is observed in an almost two-fold larger range of gleak. If the bistability is an indication of a dysfunctional dynamics, this observation describes a new, potentially pathological role of over-expression of I h and ICaF.
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This work is supported by NSF grant PHY-0750456.
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Malashchenko, T., Barnett, W., Burylko, O. et al. Control of bursting activity by modulation of ionic currents. BMC Neurosci 10, P27 (2009). https://doi.org/10.1186/1471-2202-10-S1-P27
- Animal Model
- Pharmacological Treatment
- Large Range
- Ionic Current
- Maximal Conductance