- Poster presentation
- Open Access
Influence of external input on waxing and waning of neuronal network oscillations
BMC Neuroscience volume 10, Article number: P257 (2009)
Experimental observations have reported modulation of cortical oscillations as phases of high synchronization (waxing) followed by periods of reduced synchronization (waning) [1–3]. Although the phenomenon is present in almost all frequency bands, it is still not understood how this is driven. Here we study whether this phenomenon can occur in a network of inhibitory (I) and excitatory (E) cells and what effect external inputs have.
Using NEURON, we model a network of N e excitatory and N i inhibitory cells such that N e /N i = 4. The cells have a single compartment, and include passive channels and voltage dependent Na+, K+ channels. Synaptic connections are random, projecting GABA synapses from I to I and I to E cells and AMPA synapses from E to E and E to I cells. To stimulate the network, each cell receives a baseline of current and a stream of spikes delivered at random intervals across the simulated period.
We show that in a stable oscillatory network, waxing and waning occurs without the need for other synaptic mechanisms than the spike generating K+ and Na+ channels. The phenomenon can be modulated by changing the characteristics of the external input, such as number of spikes, mean inter-spike interval, randomness and whether E or I cells receive the external input. See figures 1 and 2.
Hughes SW, Loerincz M, Cope DW, Blethyn KL, Kékesi KA, Parri HR, Juhász G, Crunelli V: Synchronized oscillations at α and β frequencies in the lateral geniculate nucleus. Neuron. 2004, 42: 253-268. 10.1016/S0896-6273(04)00191-6.
Palva S, Palva JM: New vistas for a-frequency band oscillations. Trends Neurosci. 2007, 30: 150-158. 10.1016/j.tins.2007.02.001.
Courtemanche R, Lamarre Y: Local field potential oscillations in primate cerebellar cortex: synchronization with cerebral cortex during active and passive expectancy. J Neurophysiol. 2005, 93: 2039-2052. 10.1152/jn.00080.2004.
The work was supported by the EU grant MC-RTN NEURoVERS-it (019247).
About this article
Cite this article
Gonzalez, O.J.A., van Elburg, R., Mansvelder, H. et al. Influence of external input on waxing and waning of neuronal network oscillations. BMC Neurosci 10, P257 (2009). https://doi.org/10.1186/1471-2202-10-S1-P257
- Frequency Band
- Experimental Observation
- Neuronal Network
- Simulated Period
- External Input