A mechanism underlying short-term synaptic dynamics regulated by neuromodulator based on kinetics of Ca currents
© Oh et al; licensee BioMed Central Ltd. 2009
Published: 13 July 2009
The crustacean stomatogastric nervous system (STNS) is one of the most extensively researched neural systems in studying the effects of neuromodulation. Previous studies have reported the actions of neuromodulators on intrinsic neuronal properties and synaptic strength in the STNS , but little is known about neuromodulatory effects on the short-term synaptic dynamics. We investigated the effect of the neuropeptide proctolin on the dynamics of the inhibitory synapse from the lateral pyloric (LP) to the pyloric dilator (PD) neuron in the crab pyloric network. Synaptic transmission between these neurons consists of spike-mediated and non-spike-mediated (graded) components. The graded component of this synapse shows short-term depression in control saline, but in the presence of proctolin, low-amplitude (<30 mV) presynaptic stimulation causes the facilitation , while high-amplitude (>30 mV) stimulation causes depression.
This work is supported by the NIH grant MH60605
- Atamturktur S, Manor Y, Nadim F: Proctolin enables a shift in synaptic dynamics from depression to facilitation due to the presynaptic waveform amplitude in a rhythmic network. Soc Neurosci Abst. 2004, 30.Google Scholar
- Nusbaum MP, Beenhakker MP: A small-systems approach to motor pattern generation. Nature. 2002, 417: 343-350. 10.1038/417343a.PubMedView ArticleGoogle Scholar
- Golowasch J, Marder E: Proctolin activates an inward current whose voltage dependence is modified by extracellular Ca2+. J Computational Neurosci. 1992, 12: 810-817.Google Scholar
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