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A computational model for the excitatory network of the C2 column of barrel cortex
BMC Neuroscience volume 10, Article number: P164 (2009)
Many animals, especially rodents, use whiskers as an important sensory input. One of the multiple interesting properties of the whisker sensory pathway is its somatotopic mapping. Every single whisker has a local representation in the primary sensory cortex. In this barrel cortex, each whisker is represented by a single column of cortex. The excitatory connections of the C2 barrel cortex column were researched thoroughly in .
Using these data, a model was built to mirror the measured pair to pair connectivity. This model consists of integrate and fire neurons and uses the cell counts found in the experiments. Only taking into account the excitatory population, this amounts to around 6000 neurons in the network. The neuronal properties such as threshold, resting potential, EPSP shape, etc. are fitted to the found experimental values. Through simulations we show how the distribution of synaptic weights can influence the behaviour of the network.
Lefort S, Tomm C, Floyd Sarria JC, Petersen CC: The excitatory neuronal network of the C2 barrel column in mouse primary somatosensory cortex. Neuron. 2009, 61: 301-316. 10.1016/j.neuron.2008.12.020.
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Tomm, C., Lefort, S., Sarria, J.F. et al. A computational model for the excitatory network of the C2 column of barrel cortex. BMC Neurosci 10, P164 (2009) doi:10.1186/1471-2202-10-S1-P164
- Animal Model
- Cell Count
- Computational Model
- Sensory Input
- Interesting Property