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Estimation of spectro-temporal receptive fields based on linear support vector machine classification
BMC Neuroscience volume 10, Article number: P147 (2009)
Introduction
The spectro-temporal receptive field (STRF) of a neuron is defined as the linear filter that, when convolved with the spectro-temporal representation of an arbitrary stimulus, gives a linear estimate of the evoked firing rate [1]. A common method for STRF estimation uses the spike-triggered average (STA) to compute the mean stimulus pattern preceding every spike.
Here, we present a method that not only considers stimulus patterns that evoke spikes but also those after which no spikes occur. This results in a binary classification problem. We show that the STRF model is equivalent to the structure of a linear support vector machine (SVM) and propose the use of SVMs for the estimation of the STRF. Based on this approach, we demonstrate that the obtained STRFs are a better predictor for spiking and non-spiking behavior of a neuron.
Methods and results
The SVM is trained using real spike data from anesthetized gerbils [2] and zebra finches [3]. The parts of the stimulus spectrogram preceding a spike are labeled as class 1, whereas the remaining (non spike-evoking) parts are labeled as class 0. We used 80% of the data for training and 20% for prediction. See figure 1
The predicted spike rate (bold black line) compared to the actual response smoothed with a Gaussian window of 20 ms (thin red line). The upper panel shows the result for the SVM-based method, the lower panel for the STA method. The mean coherence between actual and predicted rate is 0.23 for both methods.
Discussion
In comparison to classic STA estimation, the method proposed here is characterized by a notably finer structure in the temporal evolution of spike rate prediction. In particular the non spike-eliciting time intervals are better captured by the novel approach. This behavior is likely a result of the learning procedure employed that is based on a binary classification paradigm with a linear classifier. The averaging approach of the STA results in smoother estimates for the neuronal receptive field (due to the temporal low-pass envelope characteristics of natural stimuli), consequently producing less-detailed spike rate predictions.
References
- 1.
Theunissen FE, Sen K, Doupe AJ: Spectral-temporal receptive fields of nonlinear auditory neurons obtained using natural sounds. J Neurosci. 2000, 20: 2315-2331.
- 2.
Happel MFK, Müller SG, Anemüller J, Ohl FW: Predictability of STRFs in auditory cortex neurons depends on stimulus class. Interspeech. 2008, 670.
- 3.
STRFPAK Matlab Toolbox. [http://strfpak.berkeley.edu/]
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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Meyer, A.F., Happel, M.F., Ohl, F.W. et al. Estimation of spectro-temporal receptive fields based on linear support vector machine classification. BMC Neurosci 10, P147 (2009). https://doi.org/10.1186/1471-2202-10-S1-P147
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Keywords
- Support Vector Machine
- Binary Classification
- Zebra Finch
- Stimulus Pattern
- Linear Support Vector Machine
