Directed information structure in inter-regional cortical interactions in a visuomotor tracking task
© Lizier et al; licensee BioMed Central Ltd. 2009
Published: 13 July 2009
Distributed computation in the brain is a complex process, involving interactions between many regions in order to achieve a particular task. We present an analysis of functional Magnetic Resonance Imaging (fMRI) measurements of brain activity in 16 localized regions recorded while eight subjects (who gave informed written consent) control a mouse with their right hand to track a moving target on a computer screen. We examine the underlying interaction structure between region pairs and the changes in that structure as a function of the difficulty of the tracking task. Our approach is distinguished in using asymmetric, multivariate, information-theoretical analysis, which captures not only non-linear relationships, but also collective interactions arising from groups of up to seven voxels in each region, and the direction of these relationships.
JL thanks CSIRO and the Australian Research Council Complex Open Systems Research Network (COSNet) for their partial support of this work.
- Schreiber T: Measuring information transfer. Phys Rev Lett. 2000, 85: 461-464. 10.1103/PhysRevLett.85.461.PubMedView ArticleGoogle Scholar
- Chávez M, Jacques M, Le Van Quyen M: Statistical assessment of nonlinear causality: application to epileptic EEG signals. J Neuroscience Methods. 2003, 124: 113-128. 10.1016/S0165-0270(02)00367-9.View ArticleGoogle Scholar
- Lizier JT, Prokopenko M, Zomaya AY: Local transfer entropy as a spatiotemporal filter for complex systems. Phys Rev E. 2008, 77: 0261101-0261104. 10.1103/PhysRevE.77.026110.View ArticleGoogle Scholar
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