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Single neuron activity-dependent signal processing
BMC Neuroscience volume 10, Article number: P112 (2009)
Activity in a neural network can affect both the synaptic strengths and the intrinsic electrical properties of neurons within the network. Changes of the intrinsic properties can enhance, reduce or stabilize the neural excitability. One of the activity-dependent regulatory mechanisms is the afterhyperpolarization, generally due to the activation of K+ conductances and to a Na+/K+ pump. In many neurons, the afterhyperpolarization is modified after a period of spike activity. In the mechanosensory T neurons of the leech, a prolonged electrical activity produces an increase of the afterhyperpolarization. This is believed to induce conduction block of spikes in several regions of the neuron, which in turn may decrease presynaptic invasion of spikes and thereby decrease transmitter release. To explore this possibility, we developed a multicompartment model of a T neuron . The model incorporated empirical data describing the geometry of the cell and activity-dependent changes of the afterhyperpolarization. Simulations indicated that at some branching points activity-dependent increases of the afterhyperpolarization reduced the number of spikes transmitted from the receptive fields to the soma and beyond. Simulations also showed that the afterhyperpolarization could modulate transmission from the soma to the synaptic terminals, suggesting that it can regulate spike conduction within the presynaptic arborizations of the neuron, contributing to the synaptic depression correlated with increases in the afterhyperpolarization. In order to investigate how the afterhyperpolarization modulatory capabilities on transmission were dependent on the axonal geometry as well as on membrane properties, we developed  another multicompartment model of the mechanosensory cell, representing the reduced version of the model developed in . The simulations suggested that channel kinetics influence the afterhyperpolarization-dependent modulation of spike conduction through points of impedance mismatch. The processing or conductive features of neurons seems to be determined in the first instance by the channel kinetics of the membrane and secondarily by the axonal geometry and activity-dependent processes and noise. We have also showed  that the role of the afterhyperpolarization induced by Na+/K+ pump-activity, which consists in a slow reduction in excitability, is also involved in neuronal coding. We showed that the regulation of excitability by Na+/K+ pump-activity is necessary for the neuron to make different responses depending on the statistical context of the stimuli. We investigate the role of membrane kinetics and input conductance mismatch in the adaptation of spike bursting to stimulus statistics.
Cataldo E, Brunelli M, Byrne JH, Av-Ron E, Cai Y, Baxter DA: Computational model of touch sensory cells (T Cells) of the leech: role of the afterhyperpolarization (AHP) in activity-dependent conduction failure. J Comput Neurosci. 2005, 18: 5-24. 10.1007/s10827-005-5477-3.
Cataldo E, Brunelli M, Av-Ron E, Cai Y, Baxter DA: Geometry, activity-dependent mechanisms, membrane kinetics and channel density distribution interplay in single neuron plasticity: a computational study. Biophys Rev & Lett. 2008, 3: 135-155. 10.1142/S1793048008000666.
Arganda S, Guantes R, de Polavieja GG: Sodium pumps adapt spike bursting to stimulus statistics. Nat Neurosci. 2007, 10: 1467-1473. 10.1038/nn1982.
GGP acknowledges financial support from MCI (Spain) and Biociencia program (CAM, Spain). RG acknowledges financial support from MCI (Spain).
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Cataldo, E., Arganda, S., Guantes, R. et al. Single neuron activity-dependent signal processing. BMC Neurosci 10, P112 (2009). https://doi.org/10.1186/1471-2202-10-S1-P112
- Synaptic Depression
- Channel Kinetic
- Spike Burst
- Multicompartment Model
- Neural Excitability