Fig. 3

Characteristic responses of habenula and raphe to one light-dark cycle. (A) Schematic showing the workflow and data structures obtained from processing the raw neuronal activity data from the habenula and the Raphe. The “Unknown Model” represents an as-yet unknown model whose goal would be to use the habenula data as input to estimate raphe behaviour from the ablation experiments. (B) Characteristic responses of the six habenula subtypes to light exposure were obtained by averaging across the four light-dark periods. This was followed by padding and interpolation to extend the response trajectory to 100s so all neurons would reach the baseline, followed by smoothing. (C) Characteristic responses of raphe neurons to unablated conditions or ablation experiments were obtained from the response of individual raphe cells to the first light exposure and following dark period