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Table 7 Drug repurposing using LINCS L1000 and upregulated gene targets

From: Prodromal Parkinson disease signs are predicted by a whole-blood inflammatory transcriptional signature in young Pink1−/− rats

Drug compound

P-value

Combined Score

Genes

EPG-MCF7

0.028411517

16.93884769

TSPAN8;PKIA;CKB

MCSF-MCF7

0.030318056

16.20021062

PRNP;TSPAN8;KCNN4

HBEGF-SKBR3

0.034329088

14.85626319

CDKN2C;ACSL1;TROAP

IFNG-MCF7

0.038053691

13.80794649

PRNP;PKIA;KCNN4

  1. ACSL1, Acyl-CoA Synthetase Long Chain Family Member 1; CDKN2C, Cyclin-dependent kinase 4 inhibitor C; CKB, Creatine Kinase B; KCNN4, Potassium Calcium-Activated Channel Subfamily N Member 4; PKIA, CAMP-Dependent Protein Kinase Inhibitor Alpha; PRNP, prion protein; TSPAN8, Tetraspanin 8; TROAP, Trophinin Associated Protein
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BMC Neuroscience

ISSN: 1471-2202

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