GO biological processes 2021 | P-value | Combined score | Genes |
---|---|---|---|
Mitotic nuclear division (GO:0140014) | 2.79E−04 | 114.5941314 | GOLGA2;TPX2;KIF18B;KIFC1 |
Mitotic spindle organization (GO:0007052) | 5.53E−04 | 60.9428395 | GOLGA2;TPX2;STIL;KIFC1;BUB1 |
Positive regulation of coagulation (GO:0050820) | 7.86E−04 | 428.6577674 | DMTN;ENPP4 |
Positive regulation of hemostasis (GO:1,900,048) | 7.86E−04 | 428.6577674 | DMTN;ENPP4 |
Mitotic spindle assembly (GO:0090307) | 8.65E−04 | 125.0712864 | GOLGA2;TPX2;KIFC1 |
Positive regulation of ubiquitin protein ligase activity (GO:1,904,668) | 0.001145981 | 324.7869518 | GOLGA2;BTRC |
Regulation of cyclin-dependent protein kinase activity (GO:1,904,029) | 0.001571551 | 91.9912981 | CDKN2C;GADD45A;CCNF |
Modification-dependent protein catabolic process (GO:0019941) | 0.001669146 | 40.21420442 | UBE2H;UHRF1;UBC;NEDD4L;BTRC |
Protein modification by small protein conjugation (GO:0032446) | 0.001782978 | 27.57203266 | UBE2H;UHRF1;CCNF;UBC;NEDD4L;BTRC;TRIM31 |
Positive regulation of blood coagulation (GO:0030194) | 0.002329057 | 193.7985609 | DMTN;ENPP4 |
Negative regulation of cation transmembrane transport (GO:1,904,063) | 0.002612975 | 178.2298835 | SLC43A1;NEDD4L |
Regulation of spindle organization (GO:0090224) | 0.002612975 | 178.2298835 | TPX2;TACC3 |
Negative regulation of dephosphorylation (GO:0035305) | 0.003227035 | 152.7884929 | PPP1R15A;SH2D4A |
Microtubule nucleation (GO:0007020) | 0.003227035 | 152.7884929 | GOLGA2;TPX2 |
Calcium-mediated signaling using intracellular calcium source (GO:0035584) | 0.003556911 | 142.2838495 | PRNP;DMTN |
Negative regulation of peptidyl-serine phosphorylation (GO:0033137) | 0.003556911 | 142.2838495 | DMTN;GADD45A |
Regulation of ubiquitin protein ligase activity (GO:1,904,666) | 0.003556911 | 142.2838495 | GOLGA2;BTRC |
Ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162) | 0.003901842 | 132.9442998 | UBAP1;VPS25 |
Lipid translocation (GO:0034204) | 0.004636346 | 117.0882506 | SLC66A2;ABCA4 |
Regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0000079) | 0.005152359 | 48.39549715 | CDKN2C;GADD45A;CCNF |
Spindle assembly (GO:0051225) | 0.00550998 | 46.59461952 | GOLGA2;TPX2;KIFC1 |
Regulation of blood coagulation (GO:0030193) | 0.005847771 | 98.57186344 | DMTN;ENPP4 |
Stress-activated protein kinase signaling cascade (GO:0031098) | 0.005847771 | 98.57186344 | UBC;BTRC |
Negative regulation of phosphatase activity (GO:0010923) | 0.006280312 | 93.46052238 | PPP1R15A;SH2D4A |
Regulation of protein targeting to membrane (GO:0090313) | 0.00672701 | 88.77492914 | PRNP;DMTN |
Protein ubiquitination (GO:0016567) | 0.006991208 | 16.67867098 | UBE2H;UHRF1;CCNF;UBC;NEDD4L;BTRC;TRIM31 |
Microtubule polymerization (GO:0046785) | 0.007187738 | 84.46633049 | GOLGA2;TPX2 |
Phospholipid translocation (GO:0045332) | 0.007662373 | 80.49300114 | SLC66A2;ABCA4 |
Positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 0.007662373 | 80.49300114 | GOLGA2;BTRC |
Regulation of centrosome duplication (GO:0010824) | 0.008150791 | 76.81903446 | STIL;CCNF |
Organic acid transport (GO:0015849) | 0.008907728 | 35.28697393 | SLC16A1;ACSL1;SLC43A1 |
Organelle disassembly (GO:1,903,008) | 0.009168483 | 70.24902579 | GOLGA2;ULK1 |
Sister chromatid segregation (GO:0000819) | 0.009168483 | 70.24902579 | KIF18B;KIFC1 |
Protein destabilization (GO:0031648) | 0.009168483 | 70.24902579 | PRNP;BTRC |
Calcium-mediated signaling (GO:0019722) | 0.009401506 | 34.17553607 | PRNP;DMTN;CCRL2 |
Regulation of mitotic spindle organization (GO:0060236) | 0.009697515 | 67.30243038 | TPX2;TACC3 |
Regulation of T cell receptor signaling pathway (GO:0050856) | 0.009697515 | 67.30243038 | PRNP;KCNN4 |
Protein polyubiquitination (GO:0000209) | 0.010908959 | 17.91732573 | UBE2H;CCNF;UBC;NEDD4L;BTRC |
Regulation of phosphoprotein phosphatase activity (GO:0043666) | 0.011363906 | 59.57463692 | PPP1R15A;NUAK1 |
Regulation of protein serine/threonine kinase activity (GO:0071900) | 0.011819423 | 29.77767145 | CDKN2C;GADD45A;CCNF |
Mitotic cell cycle phase transition (GO:0044772) | 0.012146854 | 20.94178916 | CDKN2C;CCNF;TACC3;BTRC |
Positive regulation of wound healing (GO:0090303) | 0.012539725 | 55.19243818 | DMTN;ENPP4 |
Endosome organization (GO:0007032) | 0.013146749 | 53.1940064 | PHETA2;ALS2CL |
Regulation of viral transcription (GO:0046782) | 0.013146749 | 53.1940064 | SUPT4H1;TRIM31 |
Vesicle organization (GO:0016050) | 0.0163684 | 44.75221974 | PHETA2;ALS2CL |
Microtubule cytoskeleton organization involved in mitosis (GO:1,902,850) | 0.017280771 | 23.50565989 | STIL;TACC3;BUB1 |
Ubiquitin-dependent protein catabolic process (GO:0006511) | 0.017498354 | 14.17570879 | UBE2H;UHRF1;NEDD4L;UBAP1;BTRC |
Negative regulation of transcription, DNA-templated (GO:0045892) | 0.019131137 | 9.468307834 | UHRF1;GADD45A;UBC;SUPT4H1;DPF3;NEDD4L;BTRC;BAP1;DEDD2 |
Protein homotetramerization (GO:0051289) | 0.020629831 | 37.1548944 | GOLGA2;TK1 |
Negative regulation of anion transmembrane transport (GO:1,903,960) | 0.021072075 | 228.7280021 | SLC43A1 |
Protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043328) | 0.021072075 | 228.7280021 | VPS25 |
Pyrimidine ribonucleotide metabolic process (GO:0009218) | 0.021072075 | 228.7280021 | ENTPD4 |
Negative regulation of collateral sprouting (GO:0048671) | 0.021072075 | 228.7280021 | ULK1 |
Regulation of caveolin-mediated endocytosis (GO:2,001,286) | 0.021072075 | 228.7280021 | NEDD4L |
Regulation of chloride transport (GO:2,001,225) | 0.021072075 | 228.7280021 | PRNP |
Negative regulation of PERK-mediated unfolded protein response (GO:1,903,898) | 0.021072075 | 228.7280021 | PPP1R15A |
Regulation of DNA topoisomerase (ATP-hydrolyzing) activity (GO:2,000,371) | 0.021072075 | 228.7280021 | UHRF1 |
Establishment of protein localization to vacuole (GO:0072666) | 0.021072075 | 228.7280021 | VPS25 |
Ethanolamine-containing compound metabolic process (GO:0042439) | 0.021072075 | 228.7280021 | GDE1 |
Exocyst localization (GO:0051601) | 0.021072075 | 228.7280021 | EXOC3 |
Positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity (GO:2,000,373) | 0.021072075 | 228.7280021 | UHRF1 |
Positive regulation of feeding behavior (GO:2,000,253) | 0.021072075 | 228.7280021 | AGRP |
Modulation by symbiont of host autophagy (GO:0075071) | 0.021072075 | 228.7280021 | ULK1 |
N-acylethanolamine metabolic process (GO:0070291) | 0.021072075 | 228.7280021 | GDE1 |
Regulation of potassium ion transmembrane transport (GO:1,901,379) | 0.022142345 | 35.07102076 | NEDD4L;KCNN4 |
Interstrand cross-link repair (GO:0036297) | 0.022915373 | 34.09768809 | DCLRE1B;UBC |
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:0006977) | 0.02369944 | 33.16639759 | PIDD1;GADD45A |
Protein K48-linked ubiquitination (GO:0070936) | 0.02449444 | 32.27464574 | UBE2H;NEDD4L |
Pteridine-containing compound biosynthetic process (GO:0042559) | 0.025233543 | 174.4296658 | SPR |
Purine ribonucleoside catabolic process (GO:0046130) | 0.025233543 | 174.4296658 | ENPP4 |
Amino-acid betaine transport (GO:0015838) | 0.025233543 | 174.4296658 | SLC22A5 |
Regulation of anion channel activity (GO:0010359) | 0.025233543 | 174.4296658 | PRNP |
Carnitine transport (GO:0015879) | 0.025233543 | 174.4296658 | SLC22A5 |
Negative regulation of protein targeting to membrane (GO:0090315) | 0.025233543 | 174.4296658 | DMTN |
Regulation of glutamate receptor signaling pathway (GO:1,900,449) | 0.025233543 | 174.4296658 | PRNP |
Centromeric sister chromatid cohesion (GO:0070601) | 0.025233543 | 174.4296658 | BUB1 |
Regulation of long-chain fatty acid import across plasma membrane (GO:0010746) | 0.025233543 | 174.4296658 | ACSL1 |
Positive regulation of protein glycosylation (GO:0060050) | 0.025233543 | 174.4296658 | GOLGA2 |
Maintenance of DNA methylation (GO:0010216) | 0.025233543 | 174.4296658 | UHRF1 |
Metaphase/anaphase transition of cell cycle (GO:0044784) | 0.025233543 | 174.4296658 | TACC3 |
Metaphase/anaphase transition of mitotic cell cycle (GO:0007091) | 0.025233543 | 174.4296658 | TACC3 |
Monoubiquitinated protein deubiquitination (GO:0035520) | 0.025233543 | 174.4296658 | BAP1 |
Negative regulation of amino acid transport (GO:0051956) | 0.025233543 | 174.4296658 | SLC43A1 |
Phospholipid transport (GO:0015914) | 0.026116823 | 30.60067511 | SLC66A2;ABCA4 |
Selective autophagy (GO:0061912) | 0.026116823 | 30.60067511 | UBC;ULK1 |
Stress-activated MAPK cascade (GO:0051403) | 0.028629802 | 28.33369953 | UBC;BTRC |
Purine ribonucleoside metabolic process (GO:0046128) | 0.029377529 | 139.3442448 | ENPP4 |
Creatine metabolic process (GO:0006600) | 0.029377529 | 139.3442448 | CKB |
Regulation of myosin-light-chain-phosphatase activity (GO:0035507) | 0.029377529 | 139.3442448 | NUAK1 |
Piecemeal microautophagy of the nucleus (GO:0034727) | 0.029377529 | 139.3442448 | ULK1 |
Positive regulation by symbiont of host autophagy (GO:0075044) | 0.029377529 | 139.3442448 | ULK1 |
Golgi disassembly (GO:0090166) | 0.029377529 | 139.3442448 | GOLGA2 |
Response to host defenses (GO:0052200) | 0.029377529 | 139.3442448 | UBC |
Positive regulation of integrin-mediated signaling pathway (GO:2,001,046) | 0.029377529 | 139.3442448 | DMTN |
Late nucleophagy (GO:0044805) | 0.029377529 | 139.3442448 | ULK1 |
Lysosomal microautophagy (GO:0016237) | 0.029377529 | 139.3442448 | ULK1 |
Modulation by symbiont of host defense response (GO:0052031) | 0.029377529 | 139.3442448 | UBC |
Protection from non-homologous end joining at telomere (GO:0031848) | 0.029377529 | 139.3442448 | DCLRE1B |
DNA metabolic process (GO:0006259) | 0.030445636 | 12.4064909 | DCLRE1B;UHRF1;GADD45A;UBC |
Mitotic G1 DNA damage checkpoint signaling (GO:0031571) | 0.03123562 | 26.31896204 | PIDD1;GADD45A |
Actin filament reorganization (GO:0090527) | 0.033504106 | 114.9818124 | DMTN |
Negative regulation of cAMP-dependent protein kinase activity (GO:2,000,480) | 0.033504106 | 114.9818124 | PKIA |
Regulation of collateral sprouting (GO:0048670) | 0.033504106 | 114.9818124 | ULK1 |
Regulation of dendritic spine maintenance (GO:1,902,950) | 0.033504106 | 114.9818124 | PRNP |
Negative regulation of potassium ion transmembrane transporter activity (GO:1,901,017) | 0.033504106 | 114.9818124 | NEDD4L |
Negative regulation of sodium ion transport (GO:0010766) | 0.033504106 | 114.9818124 | NEDD4L |
Dendritic spine maintenance (GO:0097062) | 0.033504106 | 114.9818124 | PRNP |
Peptidyl-lysine hydroxylation (GO:0017185) | 0.033504106 | 114.9818124 | PLOD1 |
Regulation of positive chemotaxis (GO:0050926) | 0.033504106 | 114.9818124 | F7 |
Regulation of protein glycosylation (GO:0060049) | 0.033504106 | 114.9818124 | GOLGA2 |
Positive regulation of fibroblast migration (GO:0010763) | 0.033504106 | 114.9818124 | DMTN |
Positive regulation of homotypic cell–cell adhesion (GO:0034112) | 0.033504106 | 114.9818124 | DMTN |
Positive regulation of isomerase activity (GO:0010912) | 0.033504106 | 114.9818124 | UHRF1 |
Positive regulation of meiotic nuclear division (GO:0045836) | 0.033504106 | 114.9818124 | STRA8 |
Lipid import into cell (GO:0140354) | 0.033504106 | 114.9818124 | ACSL1 |
Meiotic sister chromatid cohesion (GO:0051177) | 0.033504106 | 114.9818124 | BUB1 |
TORC1 signaling (GO:0038202) | 0.033504106 | 114.9818124 | NPRL3 |
Water homeostasis (GO:0030104) | 0.033504106 | 114.9818124 | NEDD4L |
Protein tetramerization (GO:0051262) | 0.036715013 | 22.90291137 | GOLGA2;TK1 |
Regulation of cell cycle (GO:0051726) | 0.037449209 | 10.90090233 | PPP1R15A;CDKN2C;GADD45A;BAP1 |
Quaternary ammonium group transport (GO:0015697) | 0.037613345 | 97.17686109 | SLC22A5 |
Negative regulation of protein activation cascade (GO:2,000,258) | 0.037613345 | 97.17686109 | F7 |
Nucleoside diphosphate catabolic process (GO:0009134) | 0.037613345 | 97.17686109 | ENTPD4 |
Regulation of PERK-mediated unfolded protein response (GO:1,903,897) | 0.037613345 | 97.17686109 | PPP1R15A |
DNA repair (GO:0006281) | 0.038236126 | 10.75710824 | DCLRE1B;GADD45A;UBC;BAP1 |
Proteolysis involved in cellular protein catabolic process (GO:0051603) | 0.039583339 | 21.44576047 | UBC;CTSW |
DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 0.039583339 | 21.44576047 | PIDD1;GADD45A |
RNA processing (GO:0006396) | 0.040835786 | 13.12275501 | CELF3;SUPT4H1;DEDD2 |
Receptor recycling (GO:0001881) | 0.041705318 | 83.65592939 | PHETA2 |
Negative regulation of sodium ion transmembrane transport (GO:1,902,306) | 0.041705318 | 83.65592939 | NEDD4L |
Negative regulation of sodium ion transmembrane transporter activity (GO:2,000,650) | 0.041705318 | 83.65592939 | NEDD4L |
Neuron projection maintenance (GO:1,990,535) | 0.041705318 | 83.65592939 | PRNP |
Positive regulation of behavior (GO:0048520) | 0.041705318 | 83.65592939 | AGRP |
Positive regulation of circadian rhythm (GO:0042753) | 0.041705318 | 83.65592939 | BTRC |
Long-chain fatty acid import into cell (GO:0044539) | 0.041705318 | 83.65592939 | ACSL1 |
Telomere maintenance in response to DNA damage (GO:0043247) | 0.041705318 | 83.65592939 | DCLRE1B |
Modification-dependent macromolecule catabolic process (GO:0043632) | 0.041705318 | 83.65592939 | UBC |
Modulation by symbiont of host process (GO:0044003) | 0.041705318 | 83.65592939 | UBC |
Regulation of organelle assembly (GO:1,902,115) | 0.042534001 | 20.1265342 | STIL;NPRL3 |
Positive regulation of apoptotic process (GO:0043065) | 0.043157194 | 9.945815682 | PIDD1;PRNP;GADD45A;UBC |
Negative regulation of protein serine/threonine kinase activity (GO:0071901) | 0.043535419 | 19.71433284 | GADD45A;PKIA |
Negative regulation of centrosome duplication (GO:0010826) | 0.045780097 | 73.0775545 | CCNF |
Pyrimidine nucleoside salvage (GO:0043097) | 0.045780097 | 73.0775545 | TK1 |
Pyrimidine-containing compound salvage (GO:0008655) | 0.045780097 | 73.0775545 | TK1 |
Negative regulation of interleukin-17 production (GO:0032700) | 0.045780097 | 73.0775545 | PRNP |
Negative regulation of potassium ion transmembrane transport (GO:1,901,380) | 0.045780097 | 73.0775545 | NEDD4L |
Negative regulation of protein localization to cell surface (GO:2,000,009) | 0.045780097 | 73.0775545 | NEDD4L |
Negative regulation of protein maturation (GO:1,903,318) | 0.045780097 | 73.0775545 | PRNP |
Erythrocyte development (GO:0048821) | 0.045780097 | 73.0775545 | DMTN |
Golgi inheritance (GO:0048313) | 0.045780097 | 73.0775545 | GOLGA2 |
Tetrahydrobiopterin metabolic process (GO:0046146) | 0.045780097 | 73.0775545 | SPR |
Negative regulation of activated T cell proliferation (GO:0046007) | 0.045780097 | 73.0775545 | PRNP |
Regulation of mitotic cell cycle phase transition (GO:1,901,990) | 0.046095937 | 12.00589545 | TPX2;UBC;BTRC |
Negative regulation of protein modification process (GO:0031400) | 0.046591985 | 18.55228225 | PPP1R15A;PRNP |
Proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161) | 0.047968823 | 9.27259786 | CCNF;UBC;NEDD4L;BTRC |
Vascular transport (GO:0010232) | 0.049725133 | 17.4915333 | SLC22A5;SLC16A1 |
Negative regulation of calcineurin-mediated signaling (GO:0106057) | 0.049837753 | 64.60145816 | PRNP |
Negative regulation of calcineurin-NFAT signaling cascade (GO:0070885) | 0.049837753 | 64.60145816 | PRNP |
Regulation of amyloid precursor protein catabolic process (GO:1,902,991) | 0.049837753 | 64.60145816 | PRNP |
Cell cycle checkpoint signaling (GO:0000075) | 0.049837753 | 64.60145816 | BUB1 |
Regulation of feeding behavior (GO:0060259) | 0.049837753 | 64.60145816 | AGRP |
Nucleoside salvage (GO:0043174) | 0.049837753 | 64.60145816 | TK1 |
Regulation of sister chromatid cohesion (GO:0007063) | 0.049837753 | 64.60145816 | BUB1 |