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Table 4 Drug repurposing using LINCS L1000 and downregulated gene targets

From: Prodromal Parkinson disease signs are predicted by a whole-blood inflammatory transcriptional signature in young Pink1−/− rats

Drug compound

P-value

Combined score

Genes

IFNA-MCF7

2.26E−04

254.9535019

PHF11;LCN2;HERC6

IFNA-BT20

0.005922153

100.5446808

PHF11;HERC6

IFNA-SKBR3

0.006006249

99.52598888

PHF11;HERC6

IFNA-MDAMB231

0.006877312

90.20902738

PHF11;HERC6

IFNA-HS578T

0.006967409

89.35667103

PHF11;HERC6

PDGFBB-SKBR3

0.007519304

84.50918235

LAPTM4B;LCN2

BTC-MCF10A

0.008090459

80.07848334

LAPTM4B;LCN2

  1. Gene HERC6, HECT And RLD Domain Containing E3 Ubiquitin Protein Ligase Family Member 6; LAPTM4B, Lysosome-associated transmembrane protein 4B; PHF11, PHD Finger Protein 11; LCN2, Lipocalin 2
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BMC Neuroscience

ISSN: 1471-2202

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