Table 3 Gene enrichment GO Biological Process analysis of the significantly downregulated genes
GO biological processes 2021 | P-value | Combined score | Genes |
|---|---|---|---|
Positive regulation of purine nucleotide biosynthetic process (GO:1900373) | 5.27E−05 | 2384.526542 | PINK1;NOS2 |
Negative regulation of neuron apoptotic process (GO:0043524) | 0.001632573 | 246.9566012 | PINK1;LIG4 |
Innate immune response (GO:0045087) | 0.001981189 | 87.80293162 | NOS2;LCN2;MID2 |
Positive regulation of autophagy (GO:0010508) | 0.00260634 | 179.3506662 | PINK1;MID2 |
Positive regulation of cold-induced thermogenesis (GO:0120162) | 0.003019429 | 161.9703169 | ACADL;LCN2 |
Regulation of neuron apoptotic process (GO:0043523) | 0.003080796 | 159.7193234 | PINK1;LIG4 |
Negative regulation of neuron death (GO:1901215) | 0.003080796 | 159.7193234 | PINK1;LIG4 |
Positive regulation of metabolic process (GO:0009893) | 0.004071108 | 131.3781523 | ACADL;LCN2 |