Prodromal Parkinson disease signs are predicted by a whole-blood inflammatory transcriptional signature in young Pink1−/− rats

Table 1 Gene enrichment KEGG analysis of the DEG dataset

KEGG 2021 human	P-value	Combined score	Genes
Mitophagy	0.005077	48.84843934	PINK1;UBC;ULK1
Ubiquitin mediated proteolysis	0.005756	30.5893287	UBE2H;UBC;NEDD4L;BTRC
Apoptosis	0.006049	29.85283778	PIDD1;TUBA1C;GADD45A;CTSW
PPAR signaling pathway	0.006424	42.71533574	ACADL;ACSL1;UBC
Peroxisome	0.008523	36.22486703	NOS2;ACSL1;ECH1
Pathways of neurodegeneration	0.010884	13.82892126	PRNP;TUBA1C;PINK1;NOS2;UBC;ULK1;COX5B
Ferroptosis	0.018559	40.60210583	PRNP;ACSL1
Fatty acid degradation	0.020303	37.7473815	ACADL;ACSL1
Cell cycle	0.025616	18.15012594	CDKN2C;GADD45A;BUB1
Arginine and proline metabolism	0.026918	29.89881632	NOS2;CKB
Lysosome	0.027792	17.17490197	LAPTM4B;ENTPD4;CTSW
Pyrimidine metabolism	0.033181	25.03114045	ENTPD4;TK1
Amyotrophic lateral sclerosis	0.03869	9.123903065	TUBA1C;PINK1;NOS2;ULK1;COX5B
Parkinson disease	0.038692	10.64788748	TUBA1C;PINK1;UBC;COX5B
Adipocytokine signaling pathway	0.04845	17.92029129	ACSL1;AGRP

ACADL, Acyl-CoA Dehydrogenase Long Chain; ACSL1, Acyl-CoA Synthetase Long Chain Family Member 1; AGRP, Agouti Related Neuropeptide; BTRC, Beta-Transducin Repeat Containing E3 Ubiquitin Protein Ligase; BUB1, BUB1 Mitotic Checkpoint Serine/Threonine Kinase; CDKN2C, Cyclin Dependent Kinase Inhibitor 2C; CKB, Creatine Kinase B; COX5B, Cytochrome C Oxidase Subunit 5B; CTSW, Cathepsin W; ECH1, Enoyl-CoA Hydratase 1; ENTPD4, Ectonucleoside Triphosphate Diphosphohydrolase 4; GADD45A, Growth Arrest And DNA Damage Inducible Alpha; LAPTM4B, Lysosome-associated transmembrane protein 4B; NEDD4L, NEDD4 Like E3 Ubiquitin Protein Ligase; NOS2, Nitric Oxide Synthase 2; PIDD1, P53-Induced Death Domain Protein 1; PINK1, PTEN Induced Kinase 1; PRNP, Major prion protein; TK1, Thymidine Kinase 1; TUBA1C, Tubulin Alpha 1c; UBC, ubiquitin C; UBE2H, Ubiquitin Conjugating Enzyme E2 H; ULK1, Unc-51 Like Autophagy Activating Kinase 1

ISSN: 1471-2202