Fig. 8
Excitation of DAergic neuron axon terminals in the rACC alleviates the nociceptive response. A Experimental procedure schematic. B Optical fibre and virus injection model of the brain. C Fluorescence map of virus infection in the VTA and rACC; scale bars = 100 μm. D PWTs of the left plantar in each group (Control, n = 10; SI-mCherry, n = 12; SI-hM3Dq, n = 12, Two-way RM ANOVA, interaction: F(20;310) = 33.63, P < 0.001, Time: F(10;310) = 111.6, P < 0.001, Group: F(2;310) = 420.0, P < 0.001). E PWTs of the right plantar for each group (Control, n = 10; SI-mCherry, n = 12; SI-hM3Dq, n = 12, Two-way RM ANOVA, interaction: F(20;310) = 1.772, P > 0.05, Time: F(10;310) = 1.744, P > 0.05, Group: F(2;310) = 0.1191, P > 0.05). Data are represented as mean ± SEM, compared with the SI-EYFP group: *P < 0.05. **P < 0.01