Fig. 6

Excitation of DAergic neurons alleviates anxiety-like behaviour in CPP mice. A Movement tracks for each mouse group in the OFT 15 days post-plantar incision. B Total distance traveled by each group 15 days post-plantar incision (Control, n = 10; SI-mCherry, n = 12; SI-hM3Dq, n = 12, one-way ANOVA, F_(2,31) = 183.4, P < 0.0001). C Central area distance covered by each group 15 days post-plantar incision (Control, n = 10; SI-mCherry, n = 12; SI-hM3Dq, n = 12, one-way ANOVA, F_(2,31) = 23.05, P < 0.001). D Movement track diagrams for each group in the EPM 15 days post-plantar incision. E. Distance statistics in the open arm 15 days post-plantar incision for each group (Control, n = 10; SI-mCherry, n = 12; SI-hM3Dq, n = 12, one-way ANOVA, F_(2,31) = 77.58, P < 0.001). F Time statistics in the open arm 15 days post-plantar incision for each group (Control, n = 10; SI-mCherry, n = 12; SI-hM3Dq, n = 12, one-way ANOVA, F_(2,31) = 70.86, p < 0.001). Data are represented as mean ± SEM, compared with the control group, ***P < 0.001; compared with the SI-mCherry group, #P < 0.05, ##P < 0.01