Fig. 3

Pathway enrichment analysis revealing the main molecular functions of differentially expressed genes in the brain 2 h after cerebral ischemia. A Top 20 enriched molecular functions; bar plot showing the number of differentially expressed genes of each altered molecular function, sorted by increasing p-value from left to right. Each color indicates the corresponding transcriptomic dataset, and the purple color (integromics) corresponds to a subset of enriched pathways with combined evidence that were only detected by integrating the data of all groups. B Enrichment map of molecular functions altered after ischemic stroke. Nodes in the network represent molecular functions and similar molecular functions with many common genes are connected. Nodes are colored according to the supporting omics datasets. Diabetic: diabetic young male mice; Female: young female mice; Male: young male mice; Old: aged male mice