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Fig. 3 | BMC Neuroscience

Fig. 3

From: Trait anxiety is related to Nx4’s efficacy on stress-induced changes in amygdala-centered resting state functional connectivity: a placebo-controlled cross-over trial in mildly to moderately stressed healthy volunteers

Fig. 3

Trait anxiety (TA) correlates with Nx4 efficacy. On stress-induced changes in amygdala-centered resting state functional connectivity (RSFC). A Correlation of TA with Nx4 efficacy on RSFC changes from right amygdala showed a significant cluster in right amygdala and pregenual anterior cingulate cortex (pgACC)/ventro-medial prefrontal cortex (vmPFC) (p = 0.002; Family-Wise Error (FWE) corrected on cluster level). B Left and right amygdala seeds used to calculate amygdala functional network. C TA negatively correlated with Nx4 effects on stress-induced RSFC changes (contrast post-stress resting state (RS2) versus pre-stress resting state (RS1); \(RS2>RS1\)) from right amygdala to pgACC/vmPFC. The Nx4 effect takes placebo into account and is calculated as Nx4(RSFC2–RSFC1)—Placebo(RSFC2–RSFC1). Each dot in the scatter plot represents data from one participant. Normative average TA for the study population is indicated as a horizontal dashed line

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BMC Neuroscience

ISSN: 1471-2202

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