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Fig. 3 | BMC Neuroscience

Fig. 3

From: Cholesterol efflux regulator ABCA1 exerts protective role against high shear stress-induced injury of HBMECs via regulating PI3K/Akt/eNOS signaling

Fig. 3

ABCA1 overexpression counteracts HSS-induced gene regulation changes in HBMECs. A Effect of ABCA1 overexpression and siRNA on the mRNA levels of MMP9, AQP4 and CYP46 as determined by qRT-PCR. B Effect of ABCA1 overexpression and siRNA on the mRNA levels of PI3K, AKT and eNOS as determined by qRT-PCR. C Effect of ABCA1 overexpression and siRNA on the protein levels of MMP9, AQP4, CYP46 and their phosphorylated forms as determined by Western blotting. D Densitometry analysis of MMP9, AQP4 and CYP46. E Effect of ABCA1 overexpression and siRNA on the protein levels of PI3K, AKT and eNOS. F Densitometry analysis of PI3K, AKT and eNOS and their phosphorylated forms. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 among the compared groups. Full-length blots/gels are presented in Additional file 1: Figures S4 and S5

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BMC Neuroscience

ISSN: 1471-2202

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