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Fig. 4 | BMC Neuroscience

Fig. 4

From: Transcriptional landscape of human neuroblastoma cells in response to SARS-CoV-2

Fig. 4

SARS-CoV-2 infection of SK-N-SH cells induced a severe inflammatory response. A Heat maps depicting virally regulated cytokines and chemokines upon SARS-CoV-2 infection in SK-N-SH cells. Colored bar represents expressive abundance of log2 transformed values. B RT-qPCR analysis of cytokines and chemokines transcription in SK-N-SH cells upon SARS-CoV-2 infection. GAPDH was used as the internal reference. Data were presented as the mean ± standard deviation (SD) from three independent experiments. **p < 0.01, ***p < 0.001. C Western blot analysis of IL1B, IL6, and TNF in cell lysates of SK-N-SH cells after infection 24 and 72 h. ACTB was used as the loading control. D Densitometry was performed to analyze differences among the samples. *p < 0.05, **p < 0.01, ***p < 0.001. E Heat maps depicting virally regulated cytokine receptors upon SARS-CoV-2 infection in SK-N-SH cells. Colored bar represents expressive abundance of log2 transformed values. F RT-qPCR analysis of cytokine receptors transcription in SK-N-SH cells upon SARS-CoV-2 infection. GAPDH was used as the internal reference. Data were presented as the mean ± SD from three independent experiments. **p < 0.01, ***p < 0.001

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