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Fig. 2 | BMC Neuroscience

Fig. 2

From: Maternal diabetes-mediated RORA suppression contributes to gastrointestinal symptoms in autism-like mouse offspring

Fig. 2

RORA agonist and SOD mimetic ameliorate maternal diabetes-mediated autism-like behaviors in male offspring. Dams were divided into the following treatment groups: control (CTL/VEH), diabetes (STZ/VEH), diabetes plus SOD mimetic MnTBAP (STZ/MnTBAP), or diabetes plus RORA agonist SR1078 (STZ/SR1078) during pregnancy, and the subsequent male offspring were used for evaluation of autism-like behaviors. a Ultrasonic vocalization, n = 9. b Social interaction (SI) test, with total interaction time and amount of time spent following, mounting, grooming, and sniffing any body parts of the other mouse were calculated, n = 9. c, d Three-chambered social tests, n = 9. c Time spent in chamber for sociability. d Time spent in chamber for social novelty. The one-way ANOVA analysis was performed to determine statistical significance of different groups. *P < 0.05, vs. CTL/VEH group; ¶P < 0.05, vs. STZ/VEH group. Data were expressed as mean ± SD

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BMC Neuroscience

ISSN: 1471-2202

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