Fig. 3

Sociability test: time spent within 1 cm of a novel object (Obj) or a stranger mouse (S1). Times spent near Obj vs S1 are different overall (p = 0.0002, two-way ANOVA). WT and cHET mice exhibit differences in time spent with Obj vs S1 (i.e., “are sociable”; **p = 0.0026, *p = 0.0132, Šidák's multiple comparisons) while cKO mice do not (p = 0.7917, Šidák's multiple comparisons). See Table 3 for means ± SEM. Inset: Schematic (not to scale) of the experimental setup for sociability experiments. An object (Obj) was placed in one of the circles marked “α” or “β”, and a stranger mouse (S1) was kept inside the other circle. Experimental mice had the freedom to move around all three chambers