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Fig. 6 | BMC Neuroscience

Fig. 6

From: An ontogenic study of receptor mechanisms by which acute administration of low-doses of methamphetamine suppresses DOI-induced 5-HT2A-receptor mediated head-twitch response in mice

Fig. 6

Effects of the selective ɑ2-adrenergic receptor antagonist RS 79948 (0.25 mg/kg, i.p.) on the inhibitory action of MA (5 mg/kg, i.p.) on the frequency of HTR induced by DOI (1 mg/kg, i.p.) across different ages (20-, 30- and 60-day old) in mice. Compared to the corresponding Vehicle + Vehicle + DOI treatment control group at each age group, inclusion of MA (i.e. MA + Vehicle + DOI treatment group) significantly decreased the mean frequency of HTR induced by DOI in 20- and 30-day old mice, but no significant effect was seen in 60-day old mice. RS 79948 pretreatment tended to reverse the inhibitory effect of MA (i.e. MA + RS 79948 + DOI treatment group) across different ages but the effect failed to attain significance. ***p = 0.001, ****p < 0.0001 vs. Vehicle + Vehicle + DOI group. n.s.: no significant difference vs. MA + Vehicle + DOI group; two-way ANOVA followed by Bonferroni's test. n = 5 − 10 in each group. Data are presented as means ± SEM.

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BMC Neuroscience

ISSN: 1471-2202

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