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Fig. 3 | BMC Neuroscience

Fig. 3

From: An ontogenic study of receptor mechanisms by which acute administration of low-doses of methamphetamine suppresses DOI-induced 5-HT2A-receptor mediated head-twitch response in mice

Fig. 3

Suppressive effects of varying doses of the selective 5-HT2A receptor antagonist EMD 281014 (0, 0.01, 0.05 and 0.1 mg/kg, i.p.) on the frequency of HTR induced by DOI (1 mg/kg, i.p.) across different ages (20-, 30- and 60-day old) in mice. In EMD 281014 vehicle-pretreated control mice, the mean frequency of DOI-induced HTR tended to gradually decrease with increasing age, with significant differences occurring between 20- and 60-day (####p < 0.0001) and between 30- and 60-day old mice (###p = 0.0002). Varying doses of EMD 281014 suppressed DOI-induced HTR in a dose- and age-dependent manner across different ages. Compared to corresponding age-matched vehicle-pretreated control group, significant reductions were observed at all tested doses of EMD 281014 in 20- and 30-day old mice, but only at 0.05 and 0.1 mg/kg doses in 60-day old mice. *p = 0.0181, ****p < 0.0001 vs. vehicle injection; two-way ANOVA followed by Bonferroni's test. n = 6 in each group. Data are presented as means ± SEM.

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BMC Neuroscience

ISSN: 1471-2202

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