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Table 1 Clinical and imaging characteristics of DM1 and controls

From: Cerebral ventriculomegaly in myotonic dystrophy type 1: normal pressure hydrocephalus-like appearances on magnetic resonance imaging

  

DM1 (n = 112)

Controls (n = 50)

p value

Clinical characteristics

Age, mean (IQR)

44.3

(36–53)

45.7

(38–53)

0.49a

 

Sex, female (%)

48 (43)

26 (52)

0.31b

DM1 related factors

CTG repeat numbers, mean (IQR)

950 (600–1366)

NA

NA

Imaging characteristics

z-Evans Index, mean (IQR)

0.29

(0.27–0.32)

0.24

(0.23–0.26)

 < .01a

 

Callosal angle, mean (IQR)

123

(115–129)

123

(112–127)

0.83a

 

Sylvian fissure dilation, n (%)

61 (54)

2 (4)

 < .01b

 

High-convexity tightness, n (%)

9 (8)

0 (0)

0.06b

 

CS-EPVS, n (%)

35 (31)

9 (18)

0.09b

 

Temporo-polar WMH, n (%)

82 (73)

0 (0)

 < .01b

 

Pathological brain atrophy, n (%)

46 (41)

1 (2)

 < .01b

  1. DM1 = myotonic dystrophy type 1, IQR interquartile range, NA not applicable, CS-EPVS enlarged perivascular spaces in centrum semiovale; temporo-polar, WML temporo-polar white matter lesion
  2. aMann–Whitney U test
  3. bFisher’s exact test